Web of Medicine: Journal of Medicine, Practice and Nursing
Web of Medicine: Journal of Medicine, Practice and Nursing is an international medium for dissemination of original results and interpretative reviews concerning the field of medicine, medical practices and nursing. The journal emphasizes the evaluation of systems in healthcare settings. The scope of journal covers: Information systems, including national or international registration systems, hospital information systems, departmental and/or physician's office systems, document handling systems, electronic medical record systems, standardization, systems integration etc.; Computer-aided medical decision support systems using heuristic, data structure, algorithms, statistical methods as exemplified in decision theory, protocol development, artificial intelligence and, machine learning studies among other techniques to new knowledge discovering. Educational computer-based programs pertaining to medical informatics or medicine in general; Organizational, economic, social, clinical impact, ethical and cost-benefit aspects of IT applications in health care. Essential practice, management, education and health promotion skills required by medical and nursing professionals. Publication Frequency: 12 Issues Per Year (Monthly) ISSN (E): 2938-3765 IFSIJ JIF: 7.555 Journal Abbreviation: Web med.
NURSING PROCESS IN MAINTAINING THE MENTAL HEALTH OF THE POPULATION
This article discusses the importance of the nursing process in maintaining and improving the mental health of the population. It highlights the role of nurses in assessing patients’ psychological conditions, identifying mental health problems, planning appropriate care, implementing nursing interventions, and evaluating treatment outcomes. The study emphasizes the significance of effective communication, psychological support, preventive measures, and community-based healthcare services in promoting mental well-being. Furthermore, the article examines modern approaches and strategies used in nursing practice to enhance the quality of mental healthcare services.
Mental health, nursing process, psychological support, community nursing, healthcare services, mental well-being, nursing care, patient assessment, prevention, rehabilitation.
Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
CLINICAL AND LABORATORY FEATURES OF CARDIORENAL SYNDROME IN PATIENTS WITH DIABETES
Violation of the kidney filtration function is common enough among patients with cardiovascular disease (CVD), especially against disorders of carbohydrate metabolism (IGM). Renal dysfunction (PD) is associated with more frequent development of cardiovascular complications. In turn, the probability of the development of renal disease in patients with cardiovascular disease is significantly higher than in the general population. These bidirectional pathogenetic mechanisms existing between cardiovascular and kidney diseases were the basis for the formation of the cardiorenal syndrome concept. The review discusses the general parts of pathogenesis within the cardiovascular continuum. In addition, it shows the effect on metabolic disorders during CVD combined with renal dysfunction. The review reveals a recent view on the main mechanisms of cardiorenal syndrome.
CLINICAL AND PATHOGENETIC FEATURES OF POST-VACCINATION COMPLICATIONS IN CHILDREN AND IMPROVEMENT OF DIAGNOSTIC AND THERAPEUTIC METHODS
Most post-vaccination reactions have a benign and transient course, however, in some cases, neurological, allergic and systemic complications may develop that require timely diagnosis and comprehensive treatment. The article examines modern ideas about the pathogenesis, clinical and neurological manifestations of post-vaccination complications in children, highlights the methods of laboratory and instrumental diagnostics, and presents the principles of a differentiated approach to patient therapy and rehabilitation. The development of post-vaccination complications is associated with a complex interaction of immunological, inflammatory and neurometabolic processes.
Post-vaccination complications, young children, neurological disorders, diagnosis, treatment.
ROLE OF MEDICAL THERMOGRAPHY IN DETECTING NEUROPATHIC PAIN AND NERVE DYSFUNCTION
Medical thermography, particularly digital infrared thermal imaging, has emerged as a promising non-invasive diagnostic modality in neurology and pain medicine. Neuropathic pain and nerve dysfunction are frequently associated with abnormalities in autonomic regulation, vascular control, and tissue metabolism, all of which influence skin temperature distribution. Infrared thermography detects these changes by measuring emitted infrared radiation from the body surface. The physiological basis, clinical applications, diagnostic significance, advantages, limitations, and future perspectives of medical thermography in detecting neuropathic pain and nerve dysfunction.
Infrared thermography, neuropathic pain, nerve dysfunction, digital infrared thermal imaging, diabetic neuropathy, autonomic nervous system.
AGE-RELATED FEATURES OF GASTRIC AND DUODENAL PEPTIC ULCER DISEASE
Peptic ulcer disease is widespread worldwide, accounting for 10-15% of all gastrointestinal diseases. Gastric and duodenal ulcers are among the most common diseases, affecting 7-10% of the adult population. This literature review discusses current views on the pathogenesis of gastric and duodenal ulcers, including the role of Helicobacter pylori infection, in patients of various age groups. The pathogenetic characteristics and clinical and morphological manifestations of peptic ulcer disease in young and elderly individuals are examined in detail.
Duodenal ulcer, gastric ulcer, age, Helicobacter pylori, pathogenesis.
IMPROVING CASE-BASED PEDIATRICS TEACHING METHODOLOGY THROUGH AN INTEGRATIVE APPROACH
This article examines the theoretical, methodological, and practical aspects of improving pediatric teaching through clinical cases and an integrative approach. The relevance of this topic is determined by the need to prepare future physicians for comprehensive clinical thinking, interdisciplinary analysis of a child's condition, and the selection of sound diagnostic, treatment, and preventive tactics, taking into account age-related, anatomical, physiological, psychological, pedagogical, and social factors. The role of the clinical case as an educational model combining fundamental knowledge, clinical disciplines, preventive pediatrics, communication skills, and an evidence-based approach is substantiated. A methodological structure for the lesson is proposed, including preliminary preparation, group discussion, interdisciplinary data interpretation, decision-making, reflection, and assessment of student competencies.
Pediatrics, clinical cases, integrative education, teaching methods, clinical thinking, medical education, competent education, mejdistdisciplinarnost, practical skills, assessment.
CLINICAL COURSE AND TREATMENT PRINCIPLES OF PNEUMONIA IN EARLY CHILDHOOD
Pneumonia remains a leading cause of morbidity and mortality among children under five years of age globally, with an incidence of 15-20 cases per 1,000 children in those under three years. This study evaluates the clinical manifestations, etiological spectrum, and therapeutic approaches in 84 hospitalized children aged 1 month to 3 years diagnosed with community-acquired pneumonia in Fergana, Uzbekistan. Findings reveal that bacterial etiology predominated in 61.9% of cases, with Streptococcus pneumoniae identified most frequently. High-dose amoxicillin therapy demonstrated clinical resolution in 78.6% of uncomplicated cases within 5-7 days. Severity stratification and early targeted antibiotic therapy significantly reduced complication rates and hospital stay duration.
Pneumonia, community-acquired pneumonia, early childhood, Streptococcus pneumoniae, respiratory syncytial virus, amoxicillin, antibiotic therapy, lobar consolidation, bronchopneumonia, fever, tachypnea, C-reactive protein, leukocytosis, oxygen saturation, pulmonary infiltration.
TECHNOLOGY OF DEVELOPING REFLECTIVE CULTURE IN UROLOGIST-PHYSICIANS WITHIN AN INNOVATIVE EDUCATIONAL ENVIRONMENT
This article examines technology-driven approaches to cultivating reflective culture among urologist-physicians in innovative educational environments. Using structured pedagogical frameworks and simulation-based methods, the research evaluates measurable shifts in professional self-assessment, clinical decision-making, and continuous learning behavior among urology residents undergoing competency-based training programs over a 12-month observational period.
Reflective culture, urologist, innovative educational environment, competency-based medical education, simulation-based training, professional self-regulation, clinical reflexivity, metacognitive awareness, deliberate practice, digital portfolio, pedagogical technology, formative assessment, surgical skill acquisition, professional identity formation, continuous professional development.
BACTERIAL TRANSMISSION DYNAMICS IN ZOONOTIC AND HEALTHCARE-ASSOCIATED INFECTION CONTROL
Bacterial pathogens operating across zoonotic and nosocomial transmission interfaces present compounding public health challenges that single-sector control frameworks consistently fail to address. This article integrates epidemiological evidence on bacterial zoonoses - including brucellosis, salmonellosis, leptospirosis, and tularemia - with data on healthcare-associated infections driven by antimicrobial-resistant organisms, examining shared transmission determinants and common pathogen ecology. The convergence of agricultural intensification, environmental contamination, and healthcare system vulnerabilities creates conditions in which pathogens establish multi-reservoir persistence. Evidence-based synthesis of One Health surveillance architectures, biosecurity interventions, and antimicrobial stewardship programs identifies coordinated control strategies that address both community-level zoonotic burden and institutional nosocomial risk simultaneously.
Bacterial zoonoses, nosocomial infections, antimicrobial resistance, One Health, transmission dynamics, biosecurity, brucellosis, salmonellosis, ESBL, leptospirosis, healthcare-associated infections, surveillance, tularemia, epidemiology, infection control.
EPIDEMIOLOGICAL HAZARD OF ANTIBIOTIC-RESISTANT MICROORGANISMS CURRENT THREATS AND CONTROL STRATEGIES
Antibiotic-resistant microorganisms constitute one of the gravest threats to contemporary global public health, responsible for 1.27 million attributable deaths annually. This article examines the epidemiological burden of antimicrobial resistance, resistance transmission mechanisms, the clinical significance of ESKAPE pathogens in nosocomial settings, and evidence-based infection control and antibiotic stewardship strategies applicable to Central Asian healthcare institutions.
Antimicrobial resistance, ESKAPE pathogens, spongiofibrosis, extended-spectrum beta-lactamase, carbapenem resistance, New Delhi metallo-beta-lactamase, multidrug-resistant organisms, nosocomial infection, horizontal gene transfer, antibiotic stewardship, epidemiological surveillance.
MODERN APPROACHES TO DIAGNOSIS AND TREATMENT OF URETHRAL STRICTURES
Urethral stricture remains one of the most clinically challenging conditions in reconstructive urology, demanding precise diagnostic evaluation and individualized treatment selection. This article reviews contemporary diagnostic modalities and surgical techniques - including drug-coated balloon dilation, buccal mucosal graft urethroplasty, and endoscopic urethrotomy - with emphasis on comparative outcome data and evidence-based treatment algorithms from current international guidelines.
Urethral stricture, spongiofibrosis, retrograde urethrography, uroflowmetry, cystourethroscopy, direct visual internal urethrotomy, urethroplasty, buccal mucosal graft, anastomotic urethroplasty, drug-coated balloon, paclitaxel dilation, stricture recurrence, urethral reconstruction, substitution urethroplasty, voiding cystourethrography.
SEASONAL DISTRIBUTION PATTERNS OF INFLUENZA AND ACUTE RESPIRATORY VIRAL INFECTIONS EPIDEMIOLOGY, MECHANISMS, AND PREVENTION STRATEGIES
Influenza and acute respiratory viral infections (ARVIs) represent among the most significant recurring public health challenges worldwide, imposing substantial morbidity, mortality, and socioeconomic burden on populations across all income settings. Worldwide, annual seasonal influenza affects up to 1 billion people and causes 3-5 million severe cases and up to 650,000 deaths related to respiratory causes. The seasonal nature of these infections - driven by a convergence of environmental, virological, and behavioral factors - follows predictable yet complex patterns that vary by hemisphere, climate zone, pathogen type, and host population. This article provides a comprehensive, evidence-based review of the seasonal epidemiology of influenza and ARVI, examining the environmental and immunological mechanisms underlying seasonal peaks, the comparative epidemiology of major respiratory viruses, patterns in high-risk populations, and current evidence on vaccination and antiviral prophylaxis as control measures. Understanding these patterns is foundational to designing effective surveillance systems and preventive strategies.
Influenza, acute respiratory viral infection, seasonality, epidemiology, transmission, humidity, vaccination, antiviral therapy, surveillance, prevention.
ORGANIZATION OF ENDOMETRIAL CANCER PREVENTION IN UZBEKISTAN
This article examines the current organizational framework of endometrial cancer prevention in Uzbekistan. The study analyzes screening coverage, stage distribution at diagnosis, risk factor profiles, and diagnostic resource availability across four regional oncological facilities over a five-year period. Evidence-based recommendations for systemic reform of preventive care infrastructure are proposed to reduce morbidity and mortality.
Endometrial cancer, uterine body cancer, cancer prevention, screening, early detection, risk factors, adenocarcinoma, endometrial hyperplasia, transvaginal ultrasound, hysteroscopy, oncogynecology, Uzbekistan healthcare, cancer registry, prophylactic examination, metabolic syndrome.
MOLECULAR-PATHOGENETIC ASPECTS OF HIF-1α PARTICIPATION IN THE DEVELOPMENT OF INTRANATAL FETAL DEATH IN PREECLAMPSIA
This study investigates the role of hypoxia-inducible factor 1-alpha (HIF-1α) in the molecular pathogenesis of intranatal fetal death complicating preeclampsia. Using immunohistochemistry, Western blotting, and ELISA analysis of placental tissue and serum samples from 65 women, we demonstrate significantly elevated HIF-1α expression in preeclamptic placentas, correlating with sFlt-1 upregulation, PlGF suppression, and fatal perinatal outcomes.
HIF-1α, preeclampsia, intranatal fetal death, hypoxia-inducible factor, placental hypoxia, sFlt-1, PlGF, trophoblast dysfunction, immunohistochemistry, Western blot, angiogenic imbalance, molecular pathogenesis, oxidative stress, fetoplacental insufficiency, perinatology.
HISTOCHEMICAL CHARACTERISTICS OF PLACENTAL TISSUE IN WOMEN WITH CARDIAC DEFECTS
This study examines histochemical alterations in placental tissue from women with congenital and acquired cardiac defects compared to healthy controls. Applying PAS-reaction, Alcian Blue, Van Gieson, Sudan III, and hematoxylin-eosin staining to 60 specimens, we identified significant reduction in trophoblast glycogen, increased fibrinoid deposition, basement membrane thickening, stromal fibrosis, and lipid accumulation, confirming measurable hypoxic placental injury.
Cardiac defects, placental histochemistry, syncytiotrophoblast, fibrinoid necrosis, PAS-reaction, glycogen depletion, Alcian Blue staining, acid mucopolysaccharides, fetoplacental insufficiency, villous edema, stromal fibrosis, Van Gieson staining, placental ischemia, basement membrane, perinatology.
ANATOMICAL AND PHYSIOLOGICAL FEATURES OF THE HUMAN CARDIOVASCULAR SYSTEM
This article examines the fundamental anatomical aspects of the human cardiovascular system as a single, highly integrated structure that ensures hemodynamics and homeostasis. Particular attention is paid to the macro- and microstructure of the heart (myocardium, conduction system, valve apparatus), as well as the architecture of the vascular bed—the morphological differences between arteries, veins, and the microcirculatory system (capillaries). The paper describes in detail the topography of the systemic and pulmonary circulations, the mechanisms of valve regulation, and the characteristics of collateral blood flow. Understanding the detailed anatomy of the cardiovascular system is the basis for the subsequent study of cardiac pathologies and the improvement of surgical and therapeutic treatment methods. The cardiovascular system is one of the most important systems in the human body, transporting oxygen, nutrients, and hormones, as well as removing waste products. The main components of this system are the heart and blood vessels—arteries, veins, and capillaries. The heart functions as a pump, ensuring the continuous movement of blood through the systemic and pulmonary circulations. This article examines the anatomical features of the heart, the structure of the vascular system, and the functional significance of various parts of the cardiovascular system in maintaining homeostasis.
Cardiovascular system, cardiac anatomy, myocardium, cardiac conduction system, hemodynamics, arteries, veins, microcirculatory bed, systemic circulation, pulmonary circulation.
PROSPECTS FOR THE DEVELOPMENT OF THE INSTITUTION OF THE MARITAL CONTRACT IN THE REPUBLIC OF UZBEKISTAN
The article examines the main directions for developing the institution of the marital contract in the Republic of Uzbekistan, taking into account current trends in family law and foreign experience. It reveals the concept and legal nature of the marital contract, analyses the specific features of its regulation under existing legislation, and explores the principal models of legal regulation in foreign legal systems. Specific proposals are formulated for improving the Family Code of the Republic of Uzbekistan in the part concerning the marital contract, including expanding the list of permissible terms, introducing electronic notarisation, and creating a unified register of marital contracts.
Marital contract, family law, property relations of spouses, Family Code of the Republic of Uzbekistan, foreign experience, notarial certification, electronic register, improvement of legislation.
A paradigmatic shift in the structure of digital literacy in higher education determines the transition from the utilitarian development of software to the systemic inclusion of artificial intelligence (AI) technologies. This trend is critically important for high-tech medical disciplines (radiology, nuclear medicine), where AI is the modernization of syllabuses (including the experience of integrating ChatGPT Edu at the Icahn School of Medicine at Mount Sinai in 2025) significantly increases the clinical adaptability of graduates. However, the global expansion of innovation is limited by the conservatism of didactic models, the heterogeneity of digital maturity of personnel and infrastructure shortages, which in the context of developing economies (LMIC) exacerbates inequality.
Artificial intelligence (AI), innovative competencies, early diagnosis.
IMMUNE STATUS CHARACTERISTICS IN CHILDREN WITH CHRONIC TONSILLITIS ASSOCIATED WITH CYTOMEGALOVIRUS INFECTION
The elevated incidence of cytomegalovirus (CMV) infection in the pediatric population and its role in sustaining chronic inflammatory processes represent significant challenges in modern pediatrics and otorhinolaryngology. This study presents clinical and laboratory evidence supporting CMV as an important etiological factor in the chronification and recurrent course of tonsillar disease. Given the established capacity of this viral infection to induce autoimmune reactions and modify immune system function, we systematically evaluated the immunological characteristics of chronic tonsillitis in school-aged children with active CMV, with particular focus on cytokine profiles and disturbances in humoral immunity. The results provide a foundation for improving prognostic approaches and designing targeted therapeutic interventions.
Chronic tonsillitis, children, cytomegalovirus infection, immunological status, cytokines, humoral immunity, autoimmune processes.
THE IMPORTANCE OF COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING IN STROKE DIAGNOSIS
This study is devoted to a comparative analysis of the effectiveness of computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis of acute stroke. Analysis of high-impact scientific literature published between 2015 and 2026 demonstrated that non-contrast CT plays a decisive role in the rapid exclusion of intracranial hemorrhage, with a diagnostic accuracy of 95–100%. In contrast, diffusion-weighted MRI (DWI) shows superiority over CT in the early detection of ischemic changes, achieving sensitivity rates of 90–99%. CT and MRI perfusion technologies have enabled a transition from the concept of the “time window” to the “tissue window,” thereby improving the effectiveness of reperfusion therapy. In conclusion, the integration of multimodal neuroimaging and artificial intelligence algorithms represents a strategic approach that optimizes the diagnostic accuracy of stroke and improves patient prognosis.
Stroke, computed tomography, magnetic resonance imaging, reperfusion therapy, acute ischemic stroke.
HYGIENIC DEFINITIONS OF WORKING CONDITIONS OF HEMATOLOGISTS
This in the article hematologists labor conditions hygienic in terms of modern scientific literature based on analysis Analysis to the results according to , laboratory employees between biological danger factors advantage to do detected , needle injuries in 25–40% of cases meeting , blood through contagious infections danger height record Also , chemical substances effect in 20–25% of cases observation and ergonomic problems wide prevalence was determined . In the article labor hygiene modern approach — occupational hygiene program system based on risks detection , monitoring and control to do mechanism illuminated. Obtained results hematologists labor conditions improve and professional risks reduce according to scientific based conclusions to release opportunity gives .
Hematologist, biologist danger, chemical danger, needle injury, infection, ergonomic problem.
CORRELATION OF THE STATE OF THE MICROBIOCENOSIS OF THE LARGE INTESTINE WITH ALLERGIC DISEASES IN CHILDREN
Allergic diseases in children are a pressing issue in modern pediatrics and hygiene. In recent years, particular attention has been paid to the role of the intestinal microbiome in the formation of the immune response and the development of allergic pathology. Disruptions in the composition of the colonic microflora contribute to a decrease in the barrier function of the mucosa, altered immunological reactivity, and an increased risk of allergic diseases. This study examines the correlation between the state of the colonic microbiome and allergic diseases in children and identifies the role of dysbiotic disorders in the development of allergic pathology.
Intestinal microbiocenosis, dysbiosis, allergic diseases, children, intestinal microflora, allergic morbidity, immunity, correlation analysis, pediatrics, prevention.
APPLICATION OF INTRACARDIAC ECHOCARDIOGRAPHY TO MONITOR HEMODYNAMICS IN ANGIOGRAPHY
Intracardiac echocardiography (ICE) is a modern imaging technique that enables detailed monitoring of hemodynamic parameters during angiographic interventions. ICE provides real-time imaging, improves the accuracy of assessment of intracardiac structures and cardiac function, and helps reduce the risk of complications during invasive procedures. This paper examines the potential of intracardiac echocardiography for hemodynamic assessment during angiography, its diagnostic value, and its impact on the effectiveness of endovascular interventions.
Intracardiac echocardiography, hemodynamics, angiography, interventional cardiology, monitoring, endovascular interventions, cardiac imaging, ICE, cardiovascular system.
DEVELOPMENT AND GENETIC VALIDATION OF THE NCCAHSCREENF SCREENING SCALE FOR PREVENTION AND EARLY DIAGNOSIS OF NONCLASSICAL CONGENITAL ADRENAL CORTEX DYSFUNCTION IN WOMEN OF FERTILE AGE
Nonclassical congenital adrenal hyperplasia (NCCAH) remains systematically underdiagnosed in women of fertile age due to phenotypic overlap with polycystic ovary syndrome. This study presents development and genetic validation of the NCCAHSCREENF clinical screening scale, integrating hormonal, dermatological, reproductive, and molecular criteria to enhance early diagnostic precision in routine endocrinological and gynecological practice.
21-hydroxylase deficiency, CYP21A2 mutation, 17-hydroxyprogesterone, hyperandrogenism, cosyntropin stimulation test, oligomenorrhea, hirsutism, anovulation, adrenal steroidogenesis, PCOS differential diagnosis, ROC analysis, androstenedione, adrenarche, glucocorticoid insufficiency, endocrine screening.
MODERN APPROACHES TO DIAGNOSIS AND INTERDISCIPLINARY ASPECTS OF DENTAL STATUS IN CHRONIC DIFFUSE LIVER LESIONS
Chronic diffuse liver lesions are a significant medical and social problem characterized by systemic effects on the body, including organs and tissues of the oral cavity. In recent years, there has been increasing interest in studying the relationship between liver pathology and dental status, due to common pathogenetic mechanisms, including immune, metabolic, and vascular disorders. The purpose of this review article is to analyze current data on the impact of chronic diffuse liver diseases on the oral cavity and substantiate the need for an integrated diagnostic approach. Clinical manifestations, pathogenetic mechanisms, features of the dental status in chronic hepatitis and cirrhosis of the liver, as well as modern diagnostic methods and interdisciplinary interaction are considered. It has been shown that the progression of liver pathology is accompanied by a deterioration in dental parameters, which requires the integration of efforts of dentists and general practitioners.
Chronic liver diseases, dental status, cirrhosis of the liver, chronic hepatitis, oral mucosa, periodontal disease, diagnosis
One of the target organs of HIV is the nervous system: only 1/10,000 of the peripheral blood lymphocytes of AIDS patients are infected with the virus, while in brain tissue HIV affects every hundredth cell. Accordingly, one of the common manifestations of HIV/AIDS is damage to the nervous system. Neurological complications of HIV infection may be caused either by the retrovirus itself or by opportunistic infections, tumors, cerebrovascular pathology, and the toxic effects of antiretroviral drugs. The article analyzes the clinical and epidemiological features of HIV infection, damage to the nervous system in AIDS, the course of opportunistic infections, and their specific treatment among the adult population of the Samarkand region.
HIV infection, opportunistic infections, AIDS, characteristics, prevalence, nervous system, ART.
CLINICAL EFFECTIVENESS OF THE APPLICATION OF PSYCHOCORRECTION METHODS IN THE TREATMENT OF SKIN DISEASES
This study analyzes the clinical effectiveness of psychocorrection methods in the treatment of dermatological diseases based on the biopsychosocial model. The results show that cognitive-behavioral therapy (CBT) and mindfulness approaches significantly reduce clinical symptoms (PASI, DLQI) in chronic diseases such as psoriasis and atopic dermatitis. Psychological interventions have been shown to inhibit inflammatory mediators and increase patient adherence by modulating the neuroimmune system. The study demonstrates that integrating a multidisciplinary approach in dermatological practice is pathogenetically sound and therapeutically effective.
Psychodermatology, biopsychosocial model, psychocorrection, cognitive-behavioral therapy, mindfulness, psoriasis, atopic dermatitis, neuroimmunology, quality of life, adherence.
ASSESSMENT OF 6-MONTH CLINICAL OUTCOMES AND RESIDUAL RISK AFTER MYOCARDIAL INFARCTION IN ELDERLY PATIENTS WITH PRIOR COVID-19 INFECTION
The COVID-19 pandemic is increasingly recognized not only as a respiratory infection but also as a condition associated with long-term cardiovascular complications. In elderly patients, previous COVID-19 infection may enhance inflammatory and thrombotic processes, thereby increasing residual cardiovascular risk after myocardial infarction. The aim of this study was to evaluate 6-month clinical outcomes and residual risk after myocardial infarction in elderly patients with prior COVID-19 infection. The study included 105 elderly patients hospitalized with myocardial infarction in the post-COVID period at the Namangan regional branch of the Scientific and Practical Cardiology Center. Clinical examination, electrocardiography, Holter monitoring, echocardiography, laboratory tests, and coronary angiography were used for assessment. Patients were followed for six months, and mortality, rehospitalizations, recurrent myocardial infarction, arrhythmias, progression of chronic heart failure, and coronary revascularization were recorded. During follow-up, overall survival was 96.7%, while mortality reached 3.3%. Rehospitalizations occurred in 24.1% of patients, recurrent myocardial infarction in 5.2%, clinically significant arrhythmias in 20.7%, and progression of chronic heart failure in 17.2%. MACE-free survival was 75.9%, indicating persistent residual cardiovascular risk. These findings suggest that elderly patients with myocardial infarction after COVID-19 infection require careful outpatient monitoring and individualized secondary prevention.
Myocardial infarction, COVID-19, elderly patients, residual cardiovascular risk, MACE, chronic heart failure.
MODERN APPROACHES TO THE DIAGNOSIS AND TREATMENT OF GASTRITIS
Gastritis is a histologically defined inflammatory condition of the gastric mucosa with substantial global prevalence. This prospective observational study evaluated 148 patients using endoscopy, biopsy, and Helicobacter pylori testing protocols. Modern bismuth quadruple eradication therapy achieved a 91.7% success rate. Integrated diagnostic and targeted therapeutic strategies significantly reduced symptom burden and improved patient outcomes.
Gastritis, helicobacter, endoscopy, biopsy, eradication, omeprazole, clarithromycin, dyspepsia, atrophy, metaplasia, diagnosis, pathology, inflammation, gastropathy, vonoprazan.
COMPARATIVE АNALYSIS OF LIPID METABOLISM, INFLAMMATORY MARKERS, AND ENDOTHELIAL DYSFUNCTION INDICATORS IN PATIENTS WITH ISCHEMIC HEART DISEASE AND STEATOHEPATITIS
This study is devoted to the assessment of biochemical indicators associated with lipid metabolism, inflammatory markers, and endothelial dysfunction in patients with ischemic heart disease (IHD) combined with steatohepatitis. A total of 120 patients were included in the study: the main group consisted of 60 patients with IHD combined with steatohepatitis, while the control group included 60 patients with IHD without steatohepatitis. In all patients, total cholesterol, triglycerides, low-density and high-density lipoproteins, fibrinogen, C-reactive protein, homocysteine, and liver enzyme levels were analyzed at baseline and during follow-up at 6 and 12 months. The obtained results demonstrated that dyslipidemia, inflammatory processes, and biochemical indicators associated with endothelial dysfunction were more pronounced in the main group compared to the control group. Dynamic analysis showed that although many laboratory indicators improved after 6 months, partial increases in several markers were observed again at the 12-month stage. These findings indicate that metabolic and inflammatory processes in patients with concomitant IHD and steatohepatitis require long-term monitoring and careful management.
Ischemic heart disease, steatohepatitis, dyslipidemia, lipid profile, endothelial dysfunction, C-reactive protein, homocysteine, fibrinogen.