Web of Medicine: Journal of Medicine, Practice and Nursing
type: channel
description: Web of Medicine: Journal of Medicine, Practice and Nursing is an international medium for dissemination of original results and interpretative reviews concerning the field of medicine, medical practices and nursing. The journal emphasizes the evaluation of systems in healthcare settings. The scope of journal covers: Information systems, including national or international registration systems, hospital information systems, departmental and/or physician's office systems, document handling systems, electronic medical record systems, standardization, systems integration etc.; Computer-aided medical decision support systems using heuristic, data structure, algorithms, statistical methods as exemplified in decision theory, protocol development, artificial intelligence and, machine learning studies among other techniques to new knowledge discovering. Educational computer-based programs pertaining to medical informatics or medicine in general; Organizational, economic, social, clinical impact, ethical and cost-benefit aspects of IT applications in health care. Essential practice, management, education and health promotion skills required by medical and nursing professionals. Publication Frequency: 12 Issues Per Year (Monthly) ISSN (E): 2938-3765 IFSIJ JIF: 7.555 Journal Abbreviation: Web med.
publisher: Web of Journals Publishing
language: en
publication name: Web of Medicine: Journal of Medicine, Practice and Nursing
issn: 2938-3765
items: ORIGIN OF HIV INFECTION
items: THE COMPOSITION OF THE SKIN MICROBIOTA IN CHILDREN AND ITS ROLE IN THE PATHOGENESIS OF ACNE
items: NON-LACTATIONAL MASTITIS: SURGICAL MANAGEMENT AND MORPHOLOGICALLY GUIDED DECISION-MAKING ALGORITHM
items: SLEEP APNEA SYNDROME: ETIOPATHOGENESIS, CLINICAL MANIFESTATIONS, CONTEMPORARY DIAGNOSTIC APPROACHES, AND EVIDENCE BASED THERAPEUTIC STRATEGIES
items: HISTOMORPHOLOGICAL AND MORPHOMETRIC CHARACTERISTICS OF AGE-RELATED CHANGES IN KNEE MENISCI IN WOMEN: A COMPARATIVE STUDY
items: NURSING CARE IN CHILDREN WITH TYPE 1 DIABETES MELLITUS
items: HYGIENIC ASSESSMENT OF MICROMYCETE CONTAMINATION IN RESIDENTIAL BUILDINGS AND ITS ROLE IN ALLERGIC RISK: A LITERATURE REVIEW
items: NEUROPSYCHOLOGICAL INTERVENTIONS FOR ADHD AND DEVELOPMENTAL DELAY IN CHILDREN: A SYSTEMATIC LITERATURE REVIEW
items: ASSESSMENT OF CLINICAL AND IMMUNOLOGICAL FEATURES OF VARIOUS FORMS OF ALLERGIC CONJUNCTIVITIS IN CHILDREN
items: PROGNOSTIC SIGNIFICANCE OF CARDIOMETABOLIC AND GENETIC FACTORS AND ARTERIAL STIFFNESS INDICES IN THE DEVELOPMENT OF ISCHEMIC HEART DISEASE
items: ANATOMICAL AND MORPHOLOGICAL CHANGES IN THE STUMP OF THE SHIN AFTER AMPUTATION AND THEIR IMPORTANCE FOR MODERN PROSTHETICS
items: THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND ITS ROLE IN THE DEVELOPMENT OF HYPERTENSION
items: LABORATORY SIGNIFICANCE OF SYSTEMIC INFLAMMATORY MARKERS IN VARIOUS FORMS OF BRUCELLOSIS AND OPTIMIZATION OF TREATMENT
items: BIOCHEMICAL BLOOD PARAMETERS OF RABBITS FED WITH PROBIOTICS
items: DIETARY FACTORS IN DECIDUOUS TEETH CARIES: A COMPREHENSIVE ANALYSIS OF PATHOPHYSIOLOGICAL MECHANISMS AND SCIENTIFIC-THEORETICAL FOUNDATIONS
items: COVID - 19 IN PATIENTS WITH CARDIOVASCULAR DISEASES
items: CLINICAL-STATISTICAL ANALYSIS OF COMPLICATIONS FOLLOWING TOOTH EXTRACTION AND MODERN SCIENTIFIC-THEORETICAL BASES OF THEIR PRIMARY AND SECONDARY TREATMENT METHODS
items: PATHOLOGICAL ANATOMY AND CLINICAL PICTURE OF DECIDUOUS TEETH CARIES IN CHILDREN A COMPLEX ANALYSIS OF ETIOPATHOGENESIS, MORPHOLOGY AND CLINICAL COURSE BASED ON CONTEMPORARY SCIENTIFIC DATA
items: IMMUNIZATION RULES FOR PREMATURE NEWBORNS
items: THE ROLE OF HORMONAL FACTORS IN THE DEVELOPMENT OF OSTEOPOROSIS
items: CLINICAL AND PROGNOSTIC MARKERS OF CARDIORENAL SYNDROME PROGRESSION AND THEIR ROLE IN PERSONALIZED TREATMENT
items: APPLICATIONS OF ARTIFICIAL INTELLIGENCE IN HUMAN GENOMIC RESEARCH AND PRECISION MEDICINE
items: EFFECTIVENESS OF BACTERIOPHAGE THERAPY IN INFLAMMATORY DISEASES OF THE ORAL MUCOSA IN CHILDREN
items: APPLICATION OF MEDICINAL SUBSTANCES
items: NURSING CARE IN HIRUDOTHERAPY AND OXYGEN THERAPY
items: EFFECT ON POSTPARTUM DEVELOPMENT OF LYMPHOID TISSUES IN PROGENY AIRWAY WALLS DUE TO CHRONIC EXPOSURE TO AIR POLLUTANTS
items: ALLERGIC DERMATITIS IN CHILDREN: RISK FACTORS, CLINICAL MANIFESTATIONS AND PREVENTIVE MEASURES
items: IMPROVING NURSING EDUCATION IN UZBEKISTAN: A LITERATURE REVIEW OF CURRENT CHALLENGES AND INTERNATIONAL PERSPECTIVES
items: ULTRASTRUCTURAL CHARACTERISTICS OF TRUE CERVICAL EROSION (EROSIO VERA) BY SCANNING ELECTRON MICROSCOPY: A QUALITATIVE AND QUANTITATIVE ANALYSIS
items: A MODERN VIEW OF THE CYLINIC COURSE OF RHEUMATOID ARTHRITIS IN CORONAVIRUS INFECTION

ORIGIN OF HIV INFECTION
type: item
description: This scientific article discusses the current knowledge around the origin of Human Immunodeficiency Virus (HIV) infection. The paper explores the natural history of the virus before it became a global pandemic, its emergence in human populations, and its transmission routes from animal hosts to humans. Special attention is given to socio-economic, ecological, and historical factors contributing to the crossing of the species barrier and the spread of HIV infection. The article concludes with an assessment of modern-day understandings, ongoing research, and future perspectives.
subject: Articles
  topic: section
subject: HIV, origin, zoonosis, primates, emergence, social factors, virus transmission, Africa, SIV, pandemic.
  topic: keywords
creator: Dr. Begimkulova Sitora Abdurazoq qizi
creator: Dr. Muzaffarova Adiba Safarovna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-30
publication date: 2026-06-30
starting page: 149
ending page: 152

THE COMPOSITION OF THE SKIN MICROBIOTA IN CHILDREN AND ITS ROLE IN THE PATHOGENESIS OF ACNE
type: item
description: Acne is a common dermatological disease characterized by chronic inflammation of the skin and manifesting mainly in adolescence. The defeat of aesthetically significant areas inevitably reduces the quality of life of patients. This article discusses modern methods of studying the skin microbiome, describes the species composition of microorganisms in newborns and the dynamics of its changes as they grow older. Special attention is paid to the role of Cutibacterium acnes in the pathogenesis of acne as the dominant taxon in the microbiota of areas with a high density of sebaceous glands.
subject: Articles
  topic: section
subject: Children, skin, pathogenesis acne, microbiota.
  topic: keywords
creator: Uralov Shukhrat Mukhtarovich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 179
ending page: 184

NON-LACTATIONAL MASTITIS: SURGICAL MANAGEMENT AND MORPHOLOGICALLY GUIDED DECISION-MAKING ALGORITHM
type: item
description: This article systematizes current evidence on surgical treatment of non-lactational mastitis (NLM) and substantiates a differentiated operative decision-making algorithm based on ultrasound parameters of the abscess cavity and the morphological maturity of the pyogenic membrane. US-guided aspiration is shown to achieve primary success in 78–85% of cases for abscesses ≤3 cm. It is demonstrated that excision of a mature pyogenic membrane (>4 mm) constitutes a mandatory, non-optional operative component. Surgery combined with steroids is shown to reduce GLM recurrence to 4.0% versus 20.9% with steroid monotherapy, while total ductectomy for periductal mastitis reduces recurrence to 4–8% versus 28–42% with standard drainage. Integration of ultrasound parameters and pyogenic membrane morphological maturity into a unified algorithm is substantiated as an evidence-based approach to improving surgical outcomes in NLM.
subject: Articles
  topic: section
subject: Non-lactational mastitis, surgical algorithm, ultrasound-guided aspiration, VAC therapy, pyogenic membrane, periductal mastitis, ductectomy, granulomatous mastitis.
  topic: keywords
creator: Xayitov Ilkhom Bakhodirovich
creator: Babajonov Akhmadjon Bakhodirovich
creator: Tangriev Shavkat Suvonovich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 172
ending page: 178

SLEEP APNEA SYNDROME: ETIOPATHOGENESIS, CLINICAL MANIFESTATIONS, CONTEMPORARY DIAGNOSTIC APPROACHES, AND EVIDENCE BASED THERAPEUTIC STRATEGIES
type: item
description: Sleep apnea syndrome (SAS), particularly obstructive sleep apnea (OSA), has become one of the most significant challenges in modern medicine, extending beyond the fields of cardiology and endocrinology. Sleep apnea syndrome is a chronic, multifactorial disorder characterized by recurrent episodes of partial or complete cessation of breathing during sleep. This condition not only impairs normal sleep quality but also contributes to the development of severe cardiovascular, endocrine, neurological, and metabolic complications. This review comprehensively discusses the etiological factors and pathogenetic mechanisms underlying sleep apnea syndrome, the diversity of its clinical manifestations, contemporary diagnostic approaches, and current evidence-based treatment strategies. Particular emphasis is placed on continuous positive airway pressure (CPAP) therapy, which remains the gold-standard treatment for moderate-to-severe obstructive sleep apnea.
subject: Articles
  topic: section
subject: Sleep apnea syndrome; obstructive sleep apnea; polysomnography; continuous positive airway pressure; intermittent hypoxia; apnea-hypopnea index; cardiovascular complications.
  topic: keywords
creator: Umida Rakhmatulloevna Narzulaeva
creator: Erbol Imongalievich Islomov
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 159
ending page: 171

HISTOMORPHOLOGICAL AND MORPHOMETRIC CHARACTERISTICS OF AGE-RELATED CHANGES IN KNEE MENISCI IN WOMEN: A COMPARATIVE STUDY
type: item
description: Background: Age-related degeneration of the knee menisci is a major contributor to knee osteoarthritis, which disproportionately affects women, particularly after menopause. Systematic histomorphological and morphometric characterisation of meniscal ageing in women remains insufficiently studied in Central Asian populations. Objectives: To characterise histomorphological and morphometric features of age-related changes in the knee menisci of women across reproductive and post-reproductive age groups in Uzbekistan. Materials and Methods: A prospective cross-sectional study was conducted at the Branch of the Republican Specialized Scientific and Practical Medical Centre of Traumatology and Orthopaedics (Khorezm Regional Multidisciplinary Medical Centre). Meniscal specimens were obtained from 112 women stratified into four age groups: Group I (25–44 years, n=28), Group II (45–54 years, n=30), Group III (55–64 years, n=28), and Group IV (65–78 years, n=26). Specimens were stained with haematoxylin-eosin, Masson's trichrome, and Safranin-O/Fast Green. Morphometric parameters included fibrochondrocyte density (cells/mm²), collagen fibre alignment index (CFAI), and proteoglycan optical density (SafO-OD) measured by digital image analysis. Results: Fibrochondrocyte density declined significantly from 47.3±5.8 cells/mm² (Group I) to 20.1±4.4 cells/mm² (Group IV; p<0.001). CFAI increased from 11.9°±2.7° to 42.8°±7.3° (p<0.001), indicating progressive collagen disorganisation. Inner zone SafO-OD declined by 66% between Groups I and IV (0.90±0.08 vs. 0.31±0.06; p<0.001). The most rapid deterioration occurred between Groups II and III, corresponding to the perimenopausal decade. Medial menisci showed significantly greater degeneration than lateral menisci (p<0.05). Conclusions: Age-related meniscal degeneration in women from Khorezm region follows a progressive, zone-specific trajectory with accelerated deterioration during the perimenopausal period, providing a morphological ba…
subject: Articles
  topic: section
subject: Knee meniscus; age-related changes; morphology; morphometry; women; menopause; osteoarthritis; histology; Uzbekistan.
  topic: keywords
creator: Dmitriy Timofeevich Li
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 153
ending page: 158

NURSING CARE IN CHILDREN WITH TYPE 1 DIABETES MELLITUS
type: item
description: Type 1 diabetes mellitus (T1DM) is one of the most common chronic endocrine disorders affecting children and adolescents worldwide. The disease develops as a result of autoimmune destruction of pancreatic β-cells, leading to absolute insulin deficiency and persistent hyperglycemia. Unlike type 2 diabetes mellitus, children diagnosed with type 1 diabetes require lifelong insulin replacement therapy and continuous monitoring of blood glucose levels. The incidence of pediatric type 1 diabetes has increased steadily over the past decades, making it a significant public health concern. Without appropriate treatment and regular follow-up, the disease may lead to severe acute complications such as hypoglycemia, diabetic ketoacidosis, and diabetic coma, as well as long-term microvascular and macrovascular complications that negatively affect quality of life.Nursing care is an essential component of comprehensive diabetes management in children. Pediatric nurses play a crucial role in early assessment, continuous monitoring, insulin administration, nutritional counseling, prevention of complications, psychological support, and patient-family education. Effective nursing interventions contribute to maintaining optimal glycemic control, reducing hospitalization rates, preventing disease-related complications, and improving both physical and psychosocial outcomes. Furthermore, educating parents and caregivers regarding insulin administration techniques, blood glucose monitoring, carbohydrate counting, healthy nutrition, physical activity, and emergency management of hypo- and hyperglycemia significantly improves treatment adherence and disease self-management.The nursing process for children with type 1 diabetes includes systematic assessment, identification of nursing diagnoses, planning individualized nursing interventions, implementation of evidence-based care, and continuous evaluation of patient outcomes. Nurses are also responsible for recognizing early signs of metabolic…
subject: Articles
  topic: section
subject: Type 1 diabetes mellitus, children, nursing care, insulin therapy, pediatric nursing, blood glucose monitoring, hypoglycemia, diabetic ketoacidosis.
  topic: keywords
creator: Farxodova Malika Sur’at qizi
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 150
ending page: 152

HYGIENIC ASSESSMENT OF MICROMYCETE CONTAMINATION IN RESIDENTIAL BUILDINGS AND ITS ROLE IN ALLERGIC RISK: A LITERATURE REVIEW
type: item
description: This article provides a detailed review of the hygienic significance of indoor micromycete (mold) contamination in residential buildings, its structural and microclimatic determinants, and its relationship to allergic health risk, based on an analysis of international and regional literature. Mechanisms of fungal proliferation, allergenic and toxigenic species, epidemiological associations, and approaches to hygienic risk assessment and prognosis are discussed in detail within the context of the Fergana region.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Micromycetes, indoor air quality, residential buildings, allergic risk, hygienic assessment, mold contamination, Alternaria alternata, Aspergillus fumigatus, mycotoxins, microclimate, bronchial asthma, allergic rhinitis, sanitary-epidemiological monitoring, risk prognosis, environmental hygiene.
creator: Xolmirzayev Farxodjon Adxamjonovich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 145
ending page: 149

NEUROPSYCHOLOGICAL INTERVENTIONS FOR ADHD AND DEVELOPMENTAL DELAY IN CHILDREN: A SYSTEMATIC LITERATURE REVIEW
type: item
description: This article presents a systematic literature review of neuropsychological interventions targeting executive function deficits, working memory, and attentional regulation in children diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) and developmental delay (DD). Publications from 2003 to 2024 indexed in PubMed, Scopus, Web of Science, and PsycINFO were systematically searched and analysed. The review covers theoretical foundations of executive function deficits in ADHD and DD, evidence base for cognitive training, behavioural, and combined neuropsychological interventions, and moderating factors including age, comorbidity, cultural context, and implementation setting. The analysis indicates that structured neuropsychological intervention programmes produce meaningful improvements in working memory (effect sizes d = 0.40–0.87), sustained attention, and inhibitory control, with combined cognitive-behavioural approaches showing the most consistent outcomes. However, the long-term maintenance of gains and cross-cultural generalisability of findings remain insufficiently studied, particularly in Central Asian educational contexts.
subject: Articles
  topic: section
subject: ADHD, developmental delay, neuropsychological interventions, executive functions, working memory, systematic review, children.
  topic: keywords
creator: Fazilova L.G.
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 139
ending page: 144

ASSESSMENT OF CLINICAL AND IMMUNOLOGICAL FEATURES OF VARIOUS FORMS OF ALLERGIC CONJUNCTIVITIS IN CHILDREN
type: item
description: Allergic conjunctivitis is one of the most common allergic pathologies of the visual organ in children and is a serious medical and social problem due to its high prevalence, tendency to recurrent course and negative impact on the quality of life of the child. Despite the achievements of modern ophthalmology and allergology, the issues of early diagnosis, objective assessment of the activity of the inflammatory process, immunological mechanisms of disease development and control of the effectiveness of therapy remain insufficiently studied.
subject: Articles
  topic: section
subject: Allergic conjunctivitis, children, immunological parameters, IgE, IL-6, IL-10, treatment, quality of life.
  topic: keywords
creator: Tukhtaeva Matlab Ashurovna
creator: Nuraliyev Nekkadam Abdullayevich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 133
ending page: 138

PROGNOSTIC SIGNIFICANCE OF CARDIOMETABOLIC AND GENETIC FACTORS AND ARTERIAL STIFFNESS INDICES IN THE DEVELOPMENT OF ISCHEMIC HEART DISEASE
type: item
description: This article reviews the prognostic significance of cardiometabolic and genetic factors (APOB, PCSK9, MMP9, FADS1, SIRT1) and arterial stiffness indices, assessed via pulse wave velocity, in the development of ischemic heart disease (IHD), based on an analysis of existing literature. Their molecular mechanisms, clinical correlations, and approaches to improving an integral risk model are discussed in detail.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Ischemic heart disease, cardiometabolic factors, genetic polymorphism, APOB, PCSK9, MMP9, FADS1, SIRT1, arterial stiffness, pulse wave velocity, atherosclerosis, dyslipidemia, endothelial dysfunction, prognostic model, early diagnosis.
creator: Xursanov Alimjon Muratjonovich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 128
ending page: 132

ANATOMICAL AND MORPHOLOGICAL CHANGES IN THE STUMP OF THE SHIN AFTER AMPUTATION AND THEIR IMPORTANCE FOR MODERN PROSTHETICS
type: item
description: Lower limb amputation remains a pressing issue in traumatology, orthopedics, and rehabilitation. Despite advances in treatment for vascular pathologies, diabetes, and the consequences of trauma, the number of patients requiring prosthetics remains high. This review systematizes literature data on the anatomical and morphological changes in the tibia stump tissues after amputation and their impact on the functional characteristics of the prosthesis. This work is based on an analysis of domestic and international sources examining the transformation of the bone, vascular, nervous systems, and soft tissues. Theoretical conclusions are compared with practical aspects of modern prosthetics, documented during a visit to a specialized facility. It has been established that bone remodeling, microcirculatory disorders, neuroma formation, phantom pain syndrome, and soft tissue changes are key factors determining the condition of the stump. Scientific consensus indicates that taking these characteristics into account when designing prostheses reduces the risk of complications and improves the effectiveness of rehabilitation.
subject: Articles
  topic: section
subject: Lower limb amputation, lower leg stump, prosthetics, morphological changes, neuroma, phantom pain, microcirculation, rehabilitation.
  topic: keywords
creator: Khojanazarova Saulehan Jubatirovna
creator: Saipova Zamira Oybekovna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 124
ending page: 127

THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND ITS ROLE IN THE DEVELOPMENT OF HYPERTENSION
type: item
description: This article examines the role of the renin-angiotensin -aldosterone system (RAAS) in the development of arterial hypertension, as well as its pathogenesis, modern diagnostic and treatment methods. The impact of RAAS hyperactivation on vascular tone, sodium retention, and cardiovascular complications is highlighted.
subject: Articles
  topic: section
subject: Renin, angiotensin, aldosterone, hypertension, vasoconstriction, endothelium, nephropathy, myocardium, hemodynamics, atherosclerosis, hypoxia, fibrosis, sodium, catecholamine, autoregulation.
  topic: keywords
creator: Alimbekov Mustafa Odilzoda
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 121
ending page: 123

LABORATORY SIGNIFICANCE OF SYSTEMIC INFLAMMATORY MARKERS IN VARIOUS FORMS OF BRUCELLOSIS AND OPTIMIZATION OF TREATMENT
type: item
description: Human brucellosis, an endemic zoonosis triggered by intracellular pathogens of the genus Brucella, continues to pose severe clinical challenges due to its extensive systemic polymorphism and a high propensity for chronic progression. Conventional serological and bacteriological assays confirm target exposure but fail to map real-time immunological stress or track localized tissue damage during therapeutic courses. Identifying precise biochemical indicators is therefore vital to improve clinical staging and avoid long-term disability.
subject: Articles
  topic: section
subject: Brucellosis, systemic inflammation, biomarkers, cytokines, diagnosis.
  topic: keywords
creator: Tokhirov F. F.
creator: Oblokulov A. R.
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 117
ending page: 120

BIOCHEMICAL BLOOD PARAMETERS OF RABBITS FED WITH PROBIOTICS
type: item
description: This study analyses the effect of probiotic preparations on physiological processes in the rabbit organism, in particular on the erythrocyte and leukocyte counts, haemoglobin level, and other haematological blood parameters. Probiotics may exert a positive influence on the animal organism by normalising the intestinal microflora, improving the digestion of nutrients, and supporting the functioning of the immune system.
subject: Articles
  topic: section
subject: Rabbit, probiotic, blood, morphological parameters, erythrocyte, leukocyte, haemoglobin, haematological analysis, intestinal microflora, immunity.
  topic: keywords
creator: Namazova Dilnoza Irzakulovna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 113
ending page: 116

DIETARY FACTORS IN DECIDUOUS TEETH CARIES: A COMPREHENSIVE ANALYSIS OF PATHOPHYSIOLOGICAL MECHANISMS AND SCIENTIFIC-THEORETICAL FOUNDATIONS
type: item
description: This article provides a comprehensive analysis of dietary factors implicated in the development of deciduous teeth caries in children, integrating contemporary scientific evidence on the biochemical, microbiological, and pathophysiological mechanisms through which specific nutritional patterns drive caries initiation and progression. The study examines the role of fermentable carbohydrates, the frequency versus quantity paradigm of sugar exposure, the cariogenicity hierarchy among different sugar types, the protective and demineralizing properties of various food categories, and the specific pathophysiology of nursing bottle caries associated with prolonged liquid carbohydrate exposure. The findings establish that dietary cariogenicity operates through a multifactorial biochemical cascade involving bacterial fermentation, pH dynamics, and the demineralization-remineralization equilibrium, providing a mechanistic foundation for evidence-based dietary counseling in pediatric caries prevention.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Deciduous teeth caries, dietary factors, fermentable carbohydrates, cariogenicity, Streptococcus mutans, demineralization, remineralization, nursing bottle caries, sugar frequency, dental plaque biofilm, dietary counseling, early childhood caries, oral microbiome, sucrose metabolism, pH dynamics.
creator: Ibragimov Gʻayratjon Rustamovich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 108
ending page: 112

COVID - 19 IN PATIENTS WITH CARDIOVASCULAR DISEASES
type: item
description: In patients of the older age group, with additional e.g. those with hypertension, diabetes and cardiovascular system disorders, it was noted that they were more prone to the development of an acute form of the disease and the risk of death. Most patients diagnosed with confirmed COVID-19 usually have symptoms such as fever, dry cough, dyspnoe, weakness and myalgia. Less common symptoms in coronavirus diseases include headache, dizziness, nausea, abdominal pain, vomiting, and diarrhea. Patients with COVID-19 usually have respiratory symptoms such as dry cough and sore throat, which are accompanied by headaches, fever and myalgia.
subject: Articles
  topic: section
subject: COVID-19, cardiovascular diseases, clinical course, cough, arythmia, complications, treatment.
  topic: keywords
creator: Shodmonov Iskandar Sergeyevich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 104
ending page: 107

CLINICAL-STATISTICAL ANALYSIS OF COMPLICATIONS FOLLOWING TOOTH EXTRACTION AND MODERN SCIENTIFIC-THEORETICAL BASES OF THEIR PRIMARY AND SECONDARY TREATMENT METHODS
type: item
description: This article examines the principal complications arising after tooth extraction, their documented frequency distribution, predisposing risk factors, and the contemporary theoretical and clinical bases for their primary and secondary management. The study analyzes alveolar osteitis, post-extraction hemorrhage, localized infection, nerve injury, and adjacent tissue trauma as the most clinically significant post-extraction complications, presenting illustrative statistical data on their relative frequency and distribution across patient subgroups defined by systemic health status, procedural complexity, and behavioral risk factors. Evidence-based primary prevention strategies and secondary treatment approaches are reviewed within the framework of contemporary oral surgery science. The findings underscore that the majority of post-extraction complications are preventable through rigorous pre-operative assessment and standardized atraumatic procedural technique, while secondary management requires prompt clinical recognition, accurate pathophysiological classification, and targeted intervention specific to each complication type.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Tooth extraction, post-extraction complications, alveolar osteitis, dry socket, post-extraction hemorrhage, alveolar infection, nerve injury, primary prevention, secondary treatment, oral surgery, wound healing, socket management, risk factors, clinical protocol, atraumatic technique
creator: Mirzaahmedov Isfandiyor Muzaffar o‘g‘li
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 98
ending page: 103

PATHOLOGICAL ANATOMY AND CLINICAL PICTURE OF DECIDUOUS TEETH CARIES IN CHILDREN A COMPLEX ANALYSIS OF ETIOPATHOGENESIS, MORPHOLOGY AND CLINICAL COURSE BASED ON CONTEMPORARY SCIENTIFIC DATA
type: item
description: This article presents a comprehensive analysis of the etiopathogenesis, morphological characteristics, and clinical course of deciduous teeth caries in children, integrating contemporary scientific evidence on the microbiological, biochemical, and structural mechanisms underlying caries initiation and progression in the primary dentition. The study examines the distinctive histological features of deciduous enamel and dentine that render the primary dentition particularly vulnerable to rapid caries progression, reviews the principal etiological factors and their interaction within the established multifactorial caries model, and characterizes the clinical staging and presentation patterns specific to early childhood caries. The findings confirm that the pathological anatomy of deciduous caries is distinguished from permanent dentition caries by a series of structural and biological features that collectively accelerate lesion progression and necessitate earlier and more aggressive clinical intervention.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Deciduous teeth caries, early childhood caries, etiopathogenesis, pathological anatomy, enamel demineralization, dentine morphology, Streptococcus mutans, caries progression, clinical staging, primary dentition, caries morphology, pulp involvement, nursing bottle caries, caries risk factors, pediatric dentistry.
creator: Nazarov Elyor Bahtiyor oʻgʻli
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 93
ending page: 97

IMMUNIZATION RULES FOR PREMATURE NEWBORNS
type: item
description: Immunization of premature newborns is a critical component of neonatal healthcare aimed at protecting this high-risk group from severe infectious diseases. Due to the immaturity of their immune system, premature infants are more vulnerable to infections; therefore, vaccination schedules must be carefully adapted based on gestational age, birth weight, and clinical stability rather than chronological age alone. Modern clinical guidelines from the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) emphasize that most routine vaccines should be administered to premature infants according to the same chronological schedule as full-term infants, provided the newborn is clinically stable. Special attention is required for extremely low birth weight infants, particularly regarding hepatitis B vaccination, where maternal HBsAg status significantly influences timing and dosing strategy.
subject: Articles
  topic: section
subject: Premature newborns, immunization, neonatal vaccination schedule, immune system immaturity, hepatitis B vaccine, WHO guidelines, CDC recommendations, neonatal care, vaccine safety.
  topic: keywords
creator: Maxmudova Shoxida Ergashevna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 89
ending page: 92

THE ROLE OF HORMONAL FACTORS IN THE DEVELOPMENT OF OSTEOPOROSIS
type: item
description: Osteoporosis is a common systemic skeletal disease characterized by decreased bone mineral density and impaired bone quality, resulting in increased bone fragility and a higher risk of fractures. The maintenance of skeletal integrity depends on a complex network of hormonal regulators that coordinate bone formation and resorption throughout life. Among these, sex steroids, parathyroid hormone, vitamin D, glucocorticoids, growth hormone, insulin-like growth factor-1 (IGF-1), calcitonin, and thyroid hormones play key roles in preserving normal bone remodeling. Hormonal influences on bone health are particularly evident during ageing. In women, menopause-related estrogen deficiency is the major factor driving accelerated bone loss, largely through increased osteoclast activity and disruption of the regulatory pathways that maintain the balance between bone resorption and bone formation. In men, age-associated declines in testosterone and IGF-1 also contribute to progressive deterioration of both cortical and trabecular bone. This review examines the major hormonal mechanisms involved in the pathogenesis of osteoporosis and highlights recent advances in our understanding of endocrine regulation of bone metabolism. Particular attention is given to the clinical implications of these hormonal interactions for the diagnosis, prevention, and treatment of osteoporosis.
subject: Articles
  topic: section
subject: Osteoporosis, bone mineral density, estrogen deficiency, parathyroid hormone, vitamin D, testosterone, glucocorticoids, bone remodelling, hormonal factors.
  topic: keywords
creator: Musayeva Kamola Farhod qizi
creator: Supervisor: Negmatova Gulzoda Shuhratovna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 82
ending page: 88

CLINICAL AND PROGNOSTIC MARKERS OF CARDIORENAL SYNDROME PROGRESSION AND THEIR ROLE IN PERSONALIZED TREATMENT
type: item
description: Cardiorenal syndrome is a relevant problem in modern cardiology and nephrology, associated with the mutual deterioration of cardiac and renal function. This article discusses clinical and prognostic markers of cardiorenal syndrome progression, including reduced estimated glomerular filtration rate, elevated NT-proBNP levels, albuminuria, type 2 diabetes mellitus, and signs of venous congestion. It is shown that a comprehensive assessment of these parameters makes it possible to identify high-risk patients and justify a personalized approach to treatment. Individualized therapy contributes to reducing the frequency of heart failure decompensation and slowing the progression of renal dysfunction.
subject: Articles
  topic: section
subject: Cardiorenal syndrome, chronic heart failure, chronic kidney disease, albuminuria, NT-proBNP, eGFR, personalized treatment.
  topic: keywords
creator: Muminov Sh. K.
creator: Nigmonov B. B.
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 76
ending page: 81

APPLICATIONS OF ARTIFICIAL INTELLIGENCE IN HUMAN GENOMIC RESEARCH AND PRECISION MEDICINE
type: item
description: Background: The volume of human genomic data generated by whole-genome sequencing, genome-wide association studies (GWAS), and multi-omics platforms now far exceeds the interpretive capacity of conventional bioinformatic pipelines. Artificial intelligence (AI) and machine learning (ML) methods have emerged as essential tools for extracting clinically and biologically meaningful signals from these datasets. Main Findings: This review critically examines four major application domains: (1) pathogenic variant interpretation and functional annotation, where models such as AlphaFold2 and ACMG/AMP-guided ML classifiers have substantially improved resolution of variants of uncertain significance (VUS); (2) disease prediction and polygenic risk scoring, particularly for cancer and complex multifactorial conditions; (3) drug discovery and pharmacogenomics, including AI-driven target identification and personalised therapeutic selection; and (4) deep learning architectures in genomics, encompassing transformer-based sequence models, genomic foundation models such as the Nucleotide Transformer and DNABERT-2, and multi-omics integration frameworks. Significance: Despite compelling advances, critical barriers impede clinical translation: algorithmic bias arising from the historical underrepresentation of non-European ancestries in training datasets, limited model explainability, data privacy constraints, and fragmented regulatory frameworks. Federated learning and explainable AI (XAI) strategies are discussed as promising mitigation approaches. This review argues that realising the full potential of AI in precision genomic medicine requires not only technical innovation but also deliberate efforts towards equitable data collection and transparent model development.
subject: Articles
  topic: section
subject: Artificial intelligence; genomics; precision medicine; deep learning; polygenic risk scores; variant interpretation; pharmacogenomics; foundation models.
  topic: keywords
creator: D. A. Olimova
creator: Sh. S. Hamrakulova
creator: O. B. Alimova
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 68
ending page: 75

EFFECTIVENESS OF BACTERIOPHAGE THERAPY IN INFLAMMATORY DISEASES OF THE ORAL MUCOSA IN CHILDREN
type: item
description: This article describes methods for treating stomatitis that develops against the background of viral diseases in children, as well as the practical application of improved and refined techniques in this field of medicine. The ways of improving the treatment of stomatitis developing against the background of viral diseases in paediatric dentistry are analysed from a scientific standpoint. A comparative analysis of this treatment method with the treatment approaches currently used in practice is also carried out, and its practical significance is demonstrated.
subject: Articles
  topic: section
subject: Viral infections, stomatitis, bacteriophage, drug, microflora, antiseptic treatment, disinfection, antiviral therapy, regeneration, immunity.
  topic: keywords
creator: Daminova Shahnoza Badriddinovna
creator: Muhamedova Malika Sagdullayevna
creator: Erkayeva Gulruh Ruslan qizi
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 63
ending page: 68

APPLICATION OF MEDICINAL SUBSTANCES
type: item
description: The application of medicinal substances is a fundamental component of nursing and clinical practice that ensures effective prevention, treatment, and management of diseases. It involves the correct selection, dosage calculation, administration routes, and monitoring of drug effects on the human body. Safe and effective medication use requires a deep understanding of pharmacological principles, patient assessment, and adherence to clinical protocols. In modern healthcare systems, nurses play a key role in medication administration, including oral, intravenous, intramuscular, subcutaneous, inhalation, and topical routes. Each method requires specific technical skills, strict adherence to aseptic techniques, and careful observation of patient responses. Incorrect drug administration can lead to serious complications such as toxicity, allergic reactions, or therapeutic failure, highlighting the importance of precision and responsibility in nursing practice.
subject: Articles
  topic: section
subject: Medicinal substances, pharmacology, drug administration, nursing practice, dosage calculation, intravenous therapy, oral medication, intramuscular injection, patient safety
  topic: keywords
creator: Karimova Farangiz Komiljon qizi
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 59
ending page: 62

NURSING CARE IN HIRUDOTHERAPY AND OXYGEN THERAPY
type: item
description: Hirudotherapy and oxygen therapy are important therapeutic methods widely used in modern healthcare for the management of various medical conditions. Hirudotherapy, which involves the medical application of leeches, has been recognized for its anticoagulant, anti-inflammatory, analgesic, and microcirculation-enhancing effects. Oxygen therapy, on the other hand, is an essential supportive treatment used to improve tissue oxygenation in patients suffering from respiratory, cardiovascular, and other systemic disorders. Effective nursing care plays a crucial role in ensuring the safety, effectiveness, and successful outcomes of both therapeutic procedures.
subject: Articles
  topic: section
subject: Hirudotherapy, oxygen therapy, nursing care, patient monitoring, oxygen administration, medicinal leeches, infection prevention, respiratory support
  topic: keywords
creator: Rasulova Parvina Ochil qizi
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 55
ending page: 58

EFFECT ON POSTPARTUM DEVELOPMENT OF LYMPHOID TISSUES IN PROGENY AIRWAY WALLS DUE TO CHRONIC EXPOSURE TO AIR POLLUTANTS
type: item
description: In recent decades, environmental pollution has become one of the most important environmental and medical problems on a global scale. The expansion of industrial production, the acceleration of urbanization, the increase in the number of vehicles, and the development of the energy sector have led to the pollution of atmospheric air with various chemical substances. The presence of nitrogen oxides, sulfur dioxide, carbon monoxide, ozone, various aerosol particles, heavy metals, and other toxic components in the composition of atmospheric air has a significant negative impact on human health. In particular, the chronic impact of these factors can cause morphofunctional changes in the functioning of various systems of the body.
subject: Articles
  topic: section
subject: nitrogen oxides, sulfur dioxide, carbon monoxide, ozone
  topic: keywords
creator: Azizova Feruza Xusanovna
creator: To’laboyev Sunnatulla Olimjon o’g’li
creator: Abdusalomov Gayrat Abdusalomovich
creator: Mamasidikov Soatjon Sodikovich
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-09
publication date: 2026-06-09
starting page: 52
ending page: 54

ALLERGIC DERMATITIS IN CHILDREN: RISK FACTORS, CLINICAL MANIFESTATIONS AND PREVENTIVE MEASURES
type: item
description: Allergic dermatitis in children is one of the most common forms of allergic skin diseases, characterized by inflammatory skin changes, itching, and increased sensitivity of the body to various allergens. The disease significantly affects the quality of life of children and may lead to sleep disturbances, emotional disorders, and an increased risk of developing other allergic conditions. This article discusses the main causes of allergic dermatitis in children, the characteristics of its clinical course, and modern approaches to diagnosis, treatment, and prevention. Particular attention is paid to the role of hereditary predisposition, food allergens, and household allergens in the development of the disease.
subject: Articles
  topic: section
subject: Allergic dermatitis, children, allergy, skin diseases, allergens, atopic dermatitis, diagnosis, treatment, prevention, immune system.
  topic: keywords
creator: Salomova Feruza Ibodullayevna
creator: Kobiljonova Shaxnoza Rustamovna
creator: Yuldasheva Shokhistakhon Patiddin qizi
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-10
publication date: 2026-06-10
starting page: 48
ending page: 51

IMPROVING NURSING EDUCATION IN UZBEKISTAN: A LITERATURE REVIEW OF CURRENT CHALLENGES AND INTERNATIONAL PERSPECTIVES
type: item
description: Nursing education plays a critical role in strengthening healthcare systems and improving patient outcomes. As healthcare needs become increasingly complex, the demand for highly qualified nursing professionals continues to grow worldwide. Uzbekistan has undertaken substantial healthcare reforms since gaining independence; however, challenges remain in the development of nursing education and workforce competencies. This literature review examines the current state of nursing education in Uzbekistan based on the report *Improving Nursing Education in the Republic of Uzbekistan and explores international experiences, particularly those of the Republic of Korea. The review identifies major challenges related to educational standards, curriculum quality, clinical training, and professional development. Furthermore, it discusses potential strategies for modernizing nursing education and aligning it with international standards. The findings suggest that strengthening higher nursing education, implementing accreditation systems, enhancing clinical practice opportunities, and expanding advanced nursing roles are essential for improving healthcare quality and nursing professionalism in Uzbekistan.
subject: Articles
  topic: section
subject: Nursing education, nursing workforce, healthcare reform, Uzbekistan, nursing competency, higher education, Republic of Korea.
  topic: keywords
creator: Tulyaganova Dildora Sagdullayevna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-10
publication date: 2026-06-10
starting page: 43
ending page: 47

ULTRASTRUCTURAL CHARACTERISTICS OF TRUE CERVICAL EROSION (EROSIO VERA) BY SCANNING ELECTRON MICROSCOPY: A QUALITATIVE AND QUANTITATIVE ANALYSIS
type: item
description: True cervical erosion (erosio vera) is characterized by denudation of the cervical epithelium with stromal exposure, but detailed SEM characterization remains limited. This study provides qualitative and quantitative SEM analysis of microrelief, cellular morphology, intercellular interactions, and vascular changes across clinical stages. Cervical tissue from 7 patients (mean age 43.6±7.2 years) was processed for SEM and evaluated for seven ultrastructural parameters with quantitative morphometry via ImageJ. True cervical erosion showed a well-demarcated epithelial defect (mean depth 25±5 μm) with sharp margins. The defect base consistently (100%) revealed exposed stroma with fibrin threads and erythrocytes in various hemolysis stages, with active thrombus formation in all cases. Cellular polymorphism was absent (0%), plasmolemma remained intact outside the defect zone (14.3% minimal peri-lesional changes), intercellular connections were completely preserved (0% disruption), and epithelial stratification was undisturbed. Erythrocyte poikilocytosis with pre-hemolytic forms was marked, and diapedetic hemorrhages beyond the defect margin occurred in 60% of cases. Healing erosions showed fibrin sheets with early re-epithelialization. Comparison with CIN I lesions (n=10) revealed significant differences in cellular polymorphism (0% vs 80%, p<0.001), plasmolemma disruption (14.3% vs 50%, p=0.04), and intercellular connection integrity (0% vs 40% disruption, p=0.006). SEM provides definitive ultrastructural criteria for distinguishing true cervical erosion from CIN I: a sharply demarcated epithelial defect with thrombus formation, absent cellular atypia, preserved intercellular architecture, and intact stratification.
subject: Articles
  topic: section
subject: True cervical erosion, scanning electron microscopy, ultrastructure, cervical epithelium, erosio vera, microrelief, thrombus formation, fibrin, differential diagnosis.
  topic: keywords
creator: Reymnazarova Gulsara Djamalovna
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-10
publication date: 2026-06-10
starting page: 34
ending page: 42

A MODERN VIEW OF THE CYLINIC COURSE OF RHEUMATOID ARTHRITIS IN CORONAVIRUS INFECTION
type: item
description: The disease occurs predominantly in young and middle-aged individuals and leads to early disability of patients, which in turn determines the social significance and relevance of the problem. COVID-19 infection has caused new features of the course of RA, which determines the medical and social relevance of studying the problem. Rheumatoid arthritis (RA) is a rheumatological disease accompanied by joint syndrome, functionally characterized by erosive damage and destruction of joints.
subject: Articles
  topic: section
subject: Rheumatoid arthritis, COVID-19 infection, muscle and joint damage, immune-inflammatory rheumatic diseases.
  topic: keywords
creator: Barno Khikmatullaevna Abdullaeva
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-06-07
publication date: 2026-06-07
starting page: 29
ending page: 33