Web of Medicine: Journal of Medicine, Practice and Nursing
type: channel
description: Web of Medicine: Journal of Medicine, Practice and Nursing is an international medium for dissemination of original results and interpretative reviews concerning the field of medicine, medical practices and nursing. The journal emphasizes the evaluation of systems in healthcare settings. The scope of journal covers: Information systems, including national or international registration systems, hospital information systems, departmental and/or physician's office systems, document handling systems, electronic medical record systems, standardization, systems integration etc.; Computer-aided medical decision support systems using heuristic, data structure, algorithms, statistical methods as exemplified in decision theory, protocol development, artificial intelligence and, machine learning studies among other techniques to new knowledge discovering. Educational computer-based programs pertaining to medical informatics or medicine in general; Organizational, economic, social, clinical impact, ethical and cost-benefit aspects of IT applications in health care. Essential practice, management, education and health promotion skills required by medical and nursing professionals. Publication Frequency: 12 Issues Per Year (Monthly) ISSN (E): 2938-3765 IFSIJ JIF: 7.555 Journal Abbreviation: Web med.
publisher: Web of Journals Publishing
language: en
publication name: Web of Medicine: Journal of Medicine, Practice and Nursing
issn: 2938-3765
items: EVALUATION OF DIET IN PATIENTS WITH HEPATIC DISEASES AFTER COVID 19
items: IMPORTANCE OF HEALTHY NUTRITION IN LIVER DISEASES
items: THE ROLE OF CYTOKINES IN HEPATOCELLULAR INFLAMMATION
items: INFECTIOUS RISKS AND COMPLICATIONS DURING DENTAL ANESTHESIA IN THE CONTEXT OF COVID-19
items: MONITORING OF PATIENTS WITH INFLAMMATORY DISEASES OF THE MAXILLOFACIAL REGION IN THE DEPARTMENT OF MAXILLOFACIAL SURGERY AT TASHKENT STATE MEDICAL UNIVERSITY
items: MORPHOLOGICAL CHANGES IN PULMONARY VESSELS IN CORONAVIRUS INFECTION
items: DIGITAL DENTISTRY AND 3D PRINTING TECHNOLOGIES: REVOLUTIONIZING DENTAL PROSTHETICS AND ORTHODONTICS
items: EVALUATION OF PREVENTIVE MEASURES AND ION RADIATION CAPABILITIES OF MSCT IN THE DIAGNOSIS OF THORACIC ORGAN PATHOLOGIES
items: CLINICAL ANALYSIS OF RISK FACTORS FOR BREAST CANCER IN YOUNG WOMEN
items: MODERN APPROACH TO THE DIAGNOSIS AND TREATMENT OF CYSTIC PREGNANCY (REVIEW)
items: ON PREDICTING PREDICTORS OF ESOPHAGEAL AND GASTRIC PATHOLOGY DEVELOPMENT IN BRONCHIAL ASTHMA
items: STUDY OF ENZYMURIA INDICATORS IN PATIENTS WITH RENAL DYSFUNCTION AND CHRONIC HEART FAILURE
items: THE ROLE OF EARLY DETECTION AND MOLECULAR BIOMARKERS IN IMPROVING BREAST CANCER SURVIVAL RATES: A REVIEW
items: MORPHOLOGICAL CHANGES OBSERVED IN THE HEART MUSCLES AS A RESULT OF DISORDERS IN THE REGULATION OF HYPERKALEMIA, HYPOMAGNESEMIA, HYPOKALEMIA, AND HYPONATREMIA EXCHANGE
items: CLINICAL-DIAGNOSTIC AND PATHOGENETIC CHARACTERISTICS OF CEREBRAL DISORDERS IN PREMATURE NEWBORNS
items: FEATURES OF THE 24-HOUR BLOOD PRESSURE PROFILE IN PATIENTS WITH ARTERIAL HYPERTENSION AND VARIOUS CARDIAC RHYTHM DISORDERS
items: ENDOSCOPIC MONITORING OF PATIENTS WITH GASTROINTESTINAL TUMORS: MODERN APPROACHES AND PROSPECTS
items: ENDOPLASMIC RETICULUM STRESS MARKERS EXPRESSION LEVELS IN LEPTIN RESISTANCE DEVELOPMENT
items: CLINICAL MANIFESTATIONS OF METABOLIC CHANGES IN HYPOTHYROIDISM AND HYPERTHYROIDISM
items: PATHOGENESIS OF CARDIOVASCULAR COMPLICATIONS IN DIABETIC PATIENTS: A COMPREHENSIVE ANALYSIS
items: AUTISM SPECTRUM DISORDER IN CHILDREN: THE CRITICAL NEED FOR AN INTERDISCIPLINARY APPROACH
items: CLINICAL CHARACTERISTICS OF ENDOMETRIOSIS PHENOTYPES
items: ANALYSIS OF SOCIO-HYGIENIC INDICATORS IN PATIENTS WITH ORAL CAVITY CANCER
items: CAUSES AND CONSEQUENCES OF THE SALINIZATION PROCESS
items: DEVELOPING AN ENVIRONMENTALLY SAFE AND RESOURCE-SAVING BIOTECHNOLOGY FOR COTTON CULTIVATION IN THE SALINE SOILS OF BUKHARA REGION
items: INCREASING WASTEWATER TREATMENT EFFICIENCY USING HYDROBIONTS
items: EVALUATING THE EFFECTIVENESS OF A NOVEL MULTIMODAL TREATMENT FOR AVASCULAR NECROSIS OF THE HEAD OF FEMUR OF POST COVID ETIOLOGY: A RETROSPECTIVE COHORT STUDY
items: STEM GROWTH DYNAMICS IN DIFFERENT VARIETIES OF MUNG BEAN
items: CLINICAL AND LABORATORY PARAMETERS IN PREGNANT WOMEN WITH A HISTORY OF RECCURENT MISCARRIAGES
items: HYGIENIC ASSESSMENT OF THE NUTRITIONAL STATUS OF POSTTERM CHILDREN

EVALUATION OF DIET IN PATIENTS WITH HEPATIC DISEASES AFTER COVID 19
type: item
description: The COVID‑19 pandemic has had significant effects on patients with pre-existing liver diseases, influencing both disease progression and nutritional status. Proper dietary management is essential to support liver function, enhance immune response, and prevent further complications. This study evaluates the dietary habits, nutrient intake, and potential deficiencies in patients with hepatic diseases following COVID‑19 infection. Understanding these nutritional patterns can guide personalized dietary interventions to improve recovery and long-term liver health.
subject: Articles
  topic: section
subject: Hepatic diseases, COVID‑19, Nutrition, Dietary evaluation, Liver function, Nutrient intake.
  topic: keywords
creator: Zakirhodjaev S. Y.
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-10
publication date: 2025-11-10
starting page: 13
ending page: 14

IMPORTANCE OF HEALTHY NUTRITION IN LIVER DISEASES
type: item
description: Nutrition plays a critical role in the management and prevention of liver diseases. Adequate intake of macronutrients and micronutrients supports liver function, enhances immune response, and helps in tissue regeneration. Malnutrition or improper dietary habits can exacerbate liver injury, promote inflammation, and accelerate disease progression. This article emphasizes the significance of individualized dietary strategies in patients with liver disorders to improve clinical outcomes and overall quality of life.
subject: Articles
  topic: section
subject: Liver diseases, Healthy nutrition, Diet therapy, Malnutrition, Liver function, Immune support.
  topic: keywords
creator: Sherzod Yahyaevich Zakirhodjaev
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-10
publication date: 2025-11-10
starting page: 11
ending page: 12

THE ROLE OF CYTOKINES IN HEPATOCELLULAR INFLAMMATION
type: item
description: Hepatocellular inflammation is a central feature of various liver diseases and is primarily mediated by cytokines, which are key regulators of immune and inflammatory responses. This article reviews the role of pro-inflammatory and anti-inflammatory cytokines in the pathogenesis of liver injury, focusing on their effects on hepatocyte function, immune cell recruitment, and fibrogenesis. Understanding the balance between these cytokines is crucial for the development of targeted therapeutic strategies aimed at controlling liver inflammation and preventing progression to chronic liver disease and cirrhosis.
subject: Articles
  topic: section
subject: Cytokines, Hepatocellular inflammation, Liver injury, Pro-inflammatory cytokines, Anti-inflammatory cytokines, Fibrogenesis
  topic: keywords
creator: Zokirkhodjaev Sh. Y.
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-10
publication date: 2025-11-10
starting page: 8
ending page: 10

INFECTIOUS RISKS AND COMPLICATIONS DURING DENTAL ANESTHESIA IN THE CONTEXT OF COVID-19
type: item
description: The COVID-19 pandemic has significantly affected all fields of medical practice, including dentistry. Dental procedures, particularly those involving anesthesia, are associated with an increased risk of infection transmission due to the formation of aerosols and close contact between the dentist and the patient. In the context of COVID-19, these factors require strict adherence to infection control protocols and the careful selection of anesthesia methods. Patients who have recovered from COVID-19 may present with post-infectious complications such as cardiovascular instability, respiratory dysfunction, and impaired immune responses, which can influence the effectiveness and safety of anesthetic agents. Therefore, dentists should consider both the infectious risks and the systemic effects of COVID-19 when choosing anesthetic techniques and dosages. The implementation of enhanced preventive measures, including pre-procedural screening, the use of personal protective equipment, and the preference for local over general anesthesia when possible, reduces the likelihood of cross-infection and anesthesia-related complications. Understanding these risks is crucial for ensuring patient safety and optimizing dental care during and after the COVID-19 pandemic. Anesthesia plays a crucial role in modern dentistry, ensuring pain-free treatment and patient comfort. Various methods of anesthesia are used depending on the type of dental procedure, patient’s health condition, and individual pain threshold. However, despite significant progress in anesthetic techniques, complications may still occur. This article reviews the main methods of anesthesia in dentistry and discusses their potential complications. Most side effects of general anesthesia occur immediately after your operation and don’t last long. Once surgery is done and anesthesia medications are stopped, you’ll slowly wake up in the operating room or recovery room. You’ll probably feel groggy and a bit confused. You may a…
subject: Articles
  topic: section
subject: Risk factors COVID-19, Local Anesthesia,(Surface) Anesthesia Sedation, General Anesthesia.
  topic: keywords
creator: Khasanova Shahnoza Alisher qizi
creator: Do'smuxamedova Shirina Nodirbek qizi
creator: Fatxullaeva Aziza Murodjon Qizi
creator: Raximjonova Munisa Jamoliddin qizi
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-31
publication date: 2025-10-31
starting page: 278
ending page: 281

MONITORING OF PATIENTS WITH INFLAMMATORY DISEASES OF THE MAXILLOFACIAL REGION IN THE DEPARTMENT OF MAXILLOFACIAL SURGERY AT TASHKENT STATE MEDICAL UNIVERSITY
type: item
description: According to literature data, purulent-inflammatory diseases of the maxillofacial region (MFR) account for 40% to 60% of the total number of surgical dental diseases. Issues regarding the organization of care for patients with purulent-inflammatory diseases of the maxillofacial region remain relevant. Currently, the main treatment method for patients with purulent-inflammatory diseases of the maxillofacial region is comprehensive therapy, which involves combining surgical procedures (abscess incision, drainage, etc.) with the use of pharmacological agents. Prognosis of purulent-inflammatory processes in the maxillofacial region is one of the pressing issues in dentistry due to the high prevalence of these diseases, the severity of the clinical course, and the possibility of developing life-threatening complications.
subject: Articles
  topic: section
subject: Purulent-inflammatory diseases, maxillofacial region (MFR), abscesses, phlegmons, odontogenic infection, antibiotic resistance.
  topic: keywords
creator: Shomurodov K. E.
creator: Gizatullina A. M.
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-31
publication date: 2025-10-31
starting page: 273
ending page: 277

MORPHOLOGICAL CHANGES IN PULMONARY VESSELS IN CORONAVIRUS INFECTION
type: item
description: It was found that the SARS-CoV-2 pathogen is characterized by causing varying degrees of changes in the endothelium and subendothelial layers of medium-sized blood vessels (muscular arteries). In particular, intermediate foci of edema and a sharp accumulation of acidic glycosaminoglycans were detected in the endothelial and subendothelial layers of muscular arteries. In order to detect these changes using histochemical methods, Alcian blue and Van Gieson stains were used. The bodies of people who died from COVID-19 infection were autopsied within 12 hours, and during the examination, immunohistochemical examination of the lung tissue of the corpse was performed, morphological changes in the tissues were studied and analyzed. Analysis of the study results showed that a high rate of vascular endothelial cell damage was characteristic of small precapillary and capillary blood vessels.
subject: Articles
  topic: section
subject: SARS‐CoV‐2, COVID‐19, pulmonary blood vessels, histochemical, immunohistochemical, endothelium, subendothelium, thrombus.
  topic: keywords
creator: Omonov Shokhrukh Rakhimovich
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-31
publication date: 2025-10-31
starting page: 263
ending page: 272

DIGITAL DENTISTRY AND 3D PRINTING TECHNOLOGIES: REVOLUTIONIZING DENTAL PROSTHETICS AND ORTHODONTICS
type: item
description: The field of dentistry has undergone a major transformation with the integration of digital technologies and 3D printing. Traditional methods for creating dental prosthetics and orthodontic appliances are being increasingly replaced by computer-aided design (CAD), computer-aided manufacturing (CAM), intraoral scanning, and additive manufacturing techniques. These technologies enable highly accurate, customized, and efficient treatment planning, improving patient outcomes while reducing production time and material waste. 3D printing, in particular, allows rapid fabrication of crowns, bridges, dentures, surgical guides, and clear aligners with exceptional anatomical precision. It also supports minimally invasive procedures, enhances esthetic results, and improves overall patient satisfaction. Beyond conventional applications, the future of digital dentistry includes bioprinting of tissues, integration with artificial intelligence (AI) for predictive treatment planning, and automation of workflow processes, which may revolutionize personalized dental care. Despite the benefits, challenges remain, such as high initial investment costs, the need for specialized training, and standardization of digital protocols across clinics. This article reviews the current advancements in digital dentistry and 3D printing, evaluates their clinical applications, and discusses future trends for optimizing dental prosthetics and orthodontic treatment.
subject: Articles
  topic: section
subject: Digital Dentistry, 3D Printing, CAD/CAM Technology, Dental Prosthetics, Orthodontics, Bioprinting, Intraoral Scanning, Patient-Centered Care, Workflow Automation, Personalized Dentistry.
  topic: keywords
creator: Fazliddin Arzikulov
creator: Samandar Abduvohidov
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-05
publication date: 2025-11-05
starting page: 1
ending page: 7

EVALUATION OF PREVENTIVE MEASURES AND ION RADIATION CAPABILITIES OF MSCT IN THE DIAGNOSIS OF THORACIC ORGAN PATHOLOGIES
type: item
description: This article presents a comprehensive assessment of the diagnostic capabilities of multislice computed tomography (MSCT) of the thoracic organs and an analysis of the dosimetric characteristics of ionizing radiation. It discusses issues of radiation prevention, optimization of scanning parameters, and enhancement of diagnostic informativeness while reducing radiation exposure. A review of modern low-dose MSCT technologies, image reconstruction methods, and dose correction algorithms is provided. The study substantiates the high diagnostic value of MSCT in detecting lung, mediastinal, and thoracic wall pathologies.
subject: Articles
  topic: section
subject: Multislice computed tomography, thorax, dosimetry, prevention, radiation safety, diagnostics.
  topic: keywords
creator: Khamidova M. A.
creator: Rakhmonova G. E.
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-04
publication date: 2025-11-04
starting page: 261
ending page: 262

CLINICAL ANALYSIS OF RISK FACTORS FOR BREAST CANCER IN YOUNG WOMEN
type: item
description: Breast cancer in young women is more often aggressive but less common than in older women. Characteristic features include more aggressive tumor types, difficult diagnosis due to high breast tissue density, and frequent detection of the disease at late stages. Risk factors include genetic predisposition, early onset of menstruation, late first birth, and lack of breastfeeding.
subject: Articles
  topic: section
subject: Cancer, breast cancer, cancer in young women.
  topic: keywords
creator: M. S. Salomov
creator: Z. M. Zokirova
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-03
publication date: 2025-11-03
starting page: 254
ending page: 260

MODERN APPROACH TO THE DIAGNOSIS AND TREATMENT OF CYSTIC PREGNANCY (REVIEW)
type: item
description: Gestational trophoblastic disease (GTD) is a group of conditions that occur in pregnant women as a result of abnormal trophoblastic proliferation. It includes benign (complete and partial hydatidiform moles) and malignant (so-called gestational trophoblastic neoplasia) conditions. Geographic heterogeneity in the distribution of GTD has been statistically noted. While these data suggest the importance of ethnicity, the true causes may be directly related to diet, diagnostic quality, population coverage, and differences in statistical data recording.
subject: Articles
  topic: section
subject: Hydatidiform mole, trophoblastic disease, gestational diseases.
  topic: keywords
creator: M. S. Salomov
creator: G. E. Bekmirzayeva
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-03
publication date: 2025-11-03
starting page: 248
ending page: 253

ON PREDICTING PREDICTORS OF ESOPHAGEAL AND GASTRIC PATHOLOGY DEVELOPMENT IN BRONCHIAL ASTHMA
type: item
description: The article presents the results of studying the frequency and nature of esophageal and gastric lesions in bronchial asthma patients and assessing causal risk factors for their development and criteria for predicting their formation. The regimens for administering glucocorticosteroid therapy (GCS) for bronchial asthma and the daily doses of GCS were closely related to the clinical manifestations of the lesions. Smoking, alcohol consumption, consumption of very cold drinks, incorrect use of inhalers, body mass index over 30, use of systemic glucocorticosteroids at doses exceeding 10 mg/day and their prolonged use for more than 5 years, as well as the use of inhaled glucocorticosteroids at doses exceeding 1000 mcg/day and their prolonged use for more than 5 years are important prognostic factors. These factors significantly increase the likelihood of developing gastric and esophageal diseases.
subject: Articles
  topic: section
subject: Bronchial asthma, glucocorticosteroids, esophageal and gastric damage, prognostic predictors
  topic: keywords
creator: Khairulleva S. S.
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-02
publication date: 2025-11-02
starting page: 244
ending page: 247

STUDY OF ENZYMURIA INDICATORS IN PATIENTS WITH RENAL DYSFUNCTION AND CHRONIC HEART FAILURE
type: item
description: Chronic heart failure (CHF) is the most common, progressive, and unfavorable disease of the cardiovascular system, and is also the most frequent cause of patient hospitalization. According to the Framingham study, CHF incidence doubles every ten years. CHF significantly worsens patients' quality of life and increases the risk of death by up to 4 times. The annual mortality rate in patients can be 15-50%. The risk of sudden death in patients with CHF is 5 times higher than in those without chronic heart failure. The most common cause of CHF is ischemic heart disease (IHD), which accounts for 54-68.6% of patients with CHF (1,9). Myocardial infarction is one of the main causes of CHF development and is characterized by post-infarction remodeling of the left ventricle (LV): structural and functional restructuring of the LV and impairment of systolic and diastolic functions. CHF is one of the most important determinants in the development of chronic kidney disease (CKD). A number of retrospective studies have established that there is a correlation between the development of chronic heart failure (CHF) and renal dysfunction (RD), which leads to a deterioration in patients' lives (5,12). An increase in overall and cardiovascular mortality in CKD is observed even with a slight decrease in renal function and is especially pronounced in patients with cardiovascular diseases, including those with chronic heart failure (6,13). The results of epidemiological and population studies indicate that even subclinical impairment of renal function is an independent risk factor for cardiovascular complications (CVC) and mortality. It is evident that in CHF, the creatinine level is analogous to the ejection fraction and is an independent predictor of adverse outcomes (4,7). Patients with both CKD and CHF have a high risk of developing renal failure and require replacement therapy. The results of numerous epidemiological, prospective, retrospective, clinical, and specially planned studies…
subject: Articles
  topic: section
creator: Alikulov I. T.
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-02
publication date: 2025-11-02
starting page: 240
ending page: 243

THE ROLE OF EARLY DETECTION AND MOLECULAR BIOMARKERS IN IMPROVING BREAST CANCER SURVIVAL RATES: A REVIEW
type: item
description: Breast cancer remains the most prevalent malignancy among women worldwide, accounting for a significant proportion of cancer-related morbidity and mortality. Despite substantial advances in oncology, survival outcomes continue to depend heavily on early detection and molecular profiling of tumors. Early screening methods such as mammography, ultrasound, and MRI have significantly improved diagnostic accuracy and allowed detection at earlier, more treatable stages. In parallel, molecular biomarkers — including BRCA1/2, HER2, PIK3CA, TP53, and hormone receptor status (ER, PR) — have transformed breast cancer classification and management. These markers provide crucial insights into tumor aggressiveness, therapeutic responsiveness, and patient prognosis. Integrating molecular biomarker assessment with effective early detection strategies allows for precision oncology, leading to personalized treatment and improved survival rates. This review summarizes current research on early detection approaches and key molecular biomarkers in breast cancer, emphasizing their combined role in enhancing prognosis and tailoring patient-specific therapies.
subject: Articles
  topic: section
subject: Breast cancer; early detection; molecular biomarkers; BRCA1/2; HER2; hormone receptors; personalized therapy; survival rate.
  topic: keywords
creator: Dallo Salva Faekovna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-01
publication date: 2025-11-01
starting page: 235
ending page: 239

MORPHOLOGICAL CHANGES OBSERVED IN THE HEART MUSCLES AS A RESULT OF DISORDERS IN THE REGULATION OF HYPERKALEMIA, HYPOMAGNESEMIA, HYPOKALEMIA, AND HYPONATREMIA EXCHANGE
type: item
description: Mineral metabolism plays a crucial role in maintaining the structural and functional integrity of the cardiac muscle. Imbalance in macro- and microelements such as potassium, calcium, magnesium, and sodium disrupts ionic homeostasis, leading to morphological and structural changes in the heart tissue. This study focuses on examining the morphological and biochemical alterations occurring in the myocardium of rats under conditions of disturbed mineral metabolism, based on biochemical analyses.
subject: Articles
  topic: section
subject: Myocardium, rat, mineral metabolism, biochemistry, cardiomyocytes, calcium, sodium, morphology.
  topic: keywords
creator: Prof. Rasulov Khamidulla Abdullaevich
creator: Assoc. Prof. Khidirova Gulnoza Ozodovna
creator: Farhod Akhmedov Abdurazzoq ugli
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-31
publication date: 2025-10-31
starting page: 231
ending page: 234

CLINICAL-DIAGNOSTIC AND PATHOGENETIC CHARACTERISTICS OF CEREBRAL DISORDERS IN PREMATURE NEWBORNS
type: item
description: The article presents the results of an analysis of the clinical and diagnostic features and pathogenetic mechanisms of cerebral disorders in premature newborns. The leading risk factors, morphofunctional changes in the central nervous system (CNS), early diagnostic methods, and modern therapeutic approaches are discussed. It has been shown that a combination of hypoxic-ischemic, infectious-inflammatory, and metabolic factors plays a key role in the formation of neurological dysfunctions. Particular attention is paid to the importance of neurosonography and magnetic resonance imaging (MRI) in the early diagnosis of brain lesions.
subject: Articles
  topic: section
subject: Premature newborns; cerebral disorders; periventricular leukomalacia; hypoxia; neurosonography; pathogenesis; early diagnosis.
  topic: keywords
creator: Amonova Zakhro Kakhramonovna
creator: Botirova Zarina Norkhuroz kizi
creator: Amonova Zilola Kakhramonovna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-30
publication date: 2025-10-30
starting page: 227
ending page: 230

FEATURES OF THE 24-HOUR BLOOD PRESSURE PROFILE IN PATIENTS WITH ARTERIAL HYPERTENSION AND VARIOUS CARDIAC RHYTHM DISORDERS
type: item
description: The aim of the study is to analyze the characteristics of the 24-hour blood pressure (BP) profile in patients with arterial hypertension (AH) complicated by various cardiac rhythm disorders. The interrelationships between the type of arrhythmia and the parameters of 24-hour blood pressure monitoring (ABPM) are examined.
subject: Articles
  topic: section
subject: Arterial hypertension, cardiac rhythm disorders, 24-hour blood pressure profile, variability, ABPM.
  topic: keywords
creator: Nuritdinova N. Batirovna
creator: Shaolimova Z. Mirabitovna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-30
publication date: 2025-10-30
starting page: 224
ending page: 226

ENDOSCOPIC MONITORING OF PATIENTS WITH GASTROINTESTINAL TUMORS: MODERN APPROACHES AND PROSPECTS
type: item
description: Malignant tumors of the gastrointestinal (GI) tract remain one of the leading causes of cancer morbidity and mortality worldwide. Late diagnosis persists as a major challenge, with over 60% of patients being identified at stages III–IV. Endoscopic monitoring utilizing advanced mucosal visualization technologies significantly improves early detection of neoplastic lesions and precancerous conditions. The use of HD-endoscopy, narrow-band imaging (NBI), endoscopic ultrasonography, capsule endoscopy, and artificial intelligence-assisted systems has demonstrated a 25–40% reduction in mortality according to international data. The article presents an overview of current endoscopic approaches and their impact on improving oncological outcomes.
subject: Articles
  topic: section
subject: Endoscopy, early cancer, GI tract, screening, NBI, artificial intelligence.
  topic: keywords
creator: Yusupov Oybek Maksud o‘g‘li
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-30
publication date: 2025-10-30
starting page: 219
ending page: 223

ENDOPLASMIC RETICULUM STRESS MARKERS EXPRESSION LEVELS IN LEPTIN RESISTANCE DEVELOPMENT
type: item
description: This review explores the link between endoplasmic reticulum (ER) stress and leptin resistance in obesity, with a focus on women. ER dysfunction activates stress markers such as XBP1, CHOP, and GRP78, disrupting leptin signaling and promoting metabolic imbalance. Chronic overnutrition induces sustained ER stress, impairing hypothalamic and peripheral leptin pathways. Elevated expression of these markers correlates with obesity severity and metabolic dysfunction, particularly in females due to hormonal and fat distribution differences. Understanding these molecular mechanisms may guide the development of targeted therapies for obesity-related disorders.
subject: Articles
  topic: section
subject: Leptin, obesity, stress, xbp1, chop, grp78, resistance, adipose, gene, expression, women, cytokines, hormone, er, metabolism.
  topic: keywords
creator: Isaqjonova Moxinur Nodirjon qizi
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-29
publication date: 2025-10-29
starting page: 215
ending page: 218

CLINICAL MANIFESTATIONS OF METABOLIC CHANGES IN HYPOTHYROIDISM AND HYPERTHYROIDISM
type: item
description: Thyroid hormones exert profound regulatory effects on systemic metabolism, with deviations in their secretion precipitating distinctive metabolic phenotypes. This review examines the clinical and biochemical manifestations arising from metabolic alterations in hypothyroidism and hyperthyroidism. Through comparative analysis of carbohydrate, lipid, and protein metabolism alongside energy homeostasis, cardiovascular implications, and diagnostic markers, this work elucidates the pathophysiological mechanisms underlying thyroid-mediated metabolic dysfunction and emphasizes the clinical imperative for early recognition and therapeutic intervention.
subject: Articles
  topic: section
subject: Hyperthyroidism, metabolism, thyroxine, triiodothyronine, thermogenesis, lipogenesis, catabolism, gluconeogenesis, homeostasis, thyrotoxicosis, myxedema, dysmetabolism, mitochondria, lipolysis
  topic: keywords
creator: Rashidov Rustamjon Shamsiddin o’g’li
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-29
publication date: 2025-10-29
starting page: 210
ending page: 214

PATHOGENESIS OF CARDIOVASCULAR COMPLICATIONS IN DIABETIC PATIENTS: A COMPREHENSIVE ANALYSIS
type: item
description: Diabetes mellitus poses a major global health burden, with cardiovascular complications being the primary cause of illness and death. This study explores the key pathogenic mechanisms linking diabetes to cardiovascular damage, including glucose toxicity, oxidative stress, inflammation, and endothelial dysfunction. Hyperglycemia triggers metabolic disturbances, mitochondrial impairment, and vascular remodeling, while advanced glycation end products, reactive oxygen species, and cytokine activation lead to myocardial injury and atherosclerosis. Understanding these mechanisms is vital for developing effective therapeutic strategies and improving cardiovascular outcomes in diabetic patients.
subject: Articles
  topic: section
subject: Diabetes, cardiomyopathy, atherosclerosis, hyperglycemia, oxidative, stress, inflammation, endothelium, insulin, resistance, vascular, pathogenesis, cytokines, complications, metabolism.
  topic: keywords
creator: Toxirov Axrorjon Adxamjon oʻgʻli
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-29
publication date: 2025-10-29
starting page: 205
ending page: 209

AUTISM SPECTRUM DISORDER IN CHILDREN: THE CRITICAL NEED FOR AN INTERDISCIPLINARY APPROACH
type: item
description: Autism Spectrum Disorder (ASD) is a complex, heterogeneous neurodevelopmental condition characterized by persistent deficits in social communication and interaction, alongside restricted, repetitive patterns of behavior, interests, or activities. Its prevalence has risen dramatically worldwide, posing a significant public health challenge. The etiology of ASD is multifactorial, involving a strong genetic predisposition intertwined with environmental, immunological, and metabolic factors. This complexity necessitates a move beyond a singular disciplinary perspective. This comprehensive review elucidates the clinical manifestations, diagnostic criteria according to the ICD-11, and the intricate etiological landscape of ASD. We provide a detailed analysis of contemporary management strategies, encompassing psychopharmacology for co-occurring conditions, innovative biological treatments under investigation, and evidence-based behavioral interventions. A central thesis of this article is that optimal outcomes for children with ASD are achieved only through a cohesive, patient-centered, interdisciplinary approach that integrates medical, therapeutic, educational, and family-based support systems.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Autism Spectrum Disorder (ASD), Neurodevelopmental Disorder, ICD-11 Classification, Social Communication Deficits, Restricted, Repetitive, Behaviors (RRBs), Sensory Processing Differences, Heterogeneity.
creator: Ergasheva N. N.
creator: Otepbergenova G.
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-25
publication date: 2025-10-25
starting page: 200
ending page: 204

CLINICAL CHARACTERISTICS OF ENDOMETRIOSIS PHENOTYPES
type: item
description: This article presents a detailed clinical analysis of various phenotypes of endometriosis, a chronic gynecological disease characterized by the presence of endometrial-like tissue outside the uterus. The study examines the specific clinical manifestations, diagnostic criteria, and progression patterns of different phenotypes, including superficial peritoneal, ovarian, and deep infiltrating endometriosis. Attention is paid to the correlation between phenotypic diversity and disease severity, as well as treatment response. The findings highlight the importance of phenotype-oriented diagnostics and personalized therapeutic approaches in improving patient outcomes.
subject: Articles
  topic: section
subject: Endometriosis, phenotypes, clinical characteristics, diagnosis, pathology, treatment, women’s health.
  topic: keywords
creator: Khamitova Zarina Vildanovna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-25
publication date: 2025-10-25
starting page: 196
ending page: 199

ANALYSIS OF SOCIO-HYGIENIC INDICATORS IN PATIENTS WITH ORAL CAVITY CANCER
type: item
description: In assessing the socio-hygienic conditions of patients diagnosed with oral cavity cancer (OCC), the results of hygienic evaluation of physical condition indicators and the prevalence of existing diseases showed that the average age of patients was 56.2 ± 6.5 years, the average height — 165.2 ± 7.4 cm, and the average body weight — 61.5 ± 4.2 kg. The body mass index (BMI) was 21.8 ± 2.3. According to age distribution, patients were divided into five groups for analysis. The analysis of comorbid diseases revealed that K00–K93 accounted for 51.0%, I00–I99 for 40.4%, and E00–E90 for 12.7%. The evaluation of primary socio-hygienic indicators in patients diagnosed with oral cavity cancer allows for the early identification of risk factors contributing to disease development and associated comorbidities.
subject: Articles
  topic: section
subject: Oral cavity cancer (OCC), age groups, body mass index (BMI), morbidity.
  topic: keywords
creator: Ortiqov Bobomurod Baymamatovich
creator: Omonova Gulrukh Furqat’s daughter
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-24
publication date: 2025-10-24
starting page: 192
ending page: 195

CAUSES AND CONSEQUENCES OF THE SALINIZATION PROCESS
type: item
description: This article analyzes the process of soil salinization, its main causes, and its ecological and economic consequences. It discusses the natural and anthropogenic factors leading to salinization, as well as the changes occurring in the physical and chemical composition of the soil. Based on the research results, recommendations are provided for preventing and reducing the degree of salinization.
subject: Articles
  topic: section
subject: Saline soil, resources, agriculture, climate change, ecological balance.
  topic: keywords
creator: Sayfullayeva Sabinabonu Husniddinovna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-23
publication date: 2025-10-23
starting page: 189
ending page: 191

DEVELOPING AN ENVIRONMENTALLY SAFE AND RESOURCE-SAVING BIOTECHNOLOGY FOR COTTON CULTIVATION IN THE SALINE SOILS OF BUKHARA REGION
type: item
description: This article analyzes resource-saving and environmentally safe biotechnological approaches to cotton cultivation on saline soils of the Bukhara region. It examines the factors affecting cotton growth under salinity conditions, biotic and abiotic methods of soil improvement, as well as new technologies developed based on biofertilizers, microorganisms, and green microalgae. The results of the research identify opportunities to increase cotton yield, reduce water and mineral fertilizer consumption, and ensure environmental sustainability.
subject: Articles
  topic: section
subject: Resource saving, environmental safety, green micro-waters, microorganisms, biostimulant, biofertilizer, cotton, saline soil.
  topic: keywords
creator: Sayfullayeva Sabinabonu Husniddinovna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-23
publication date: 2025-10-23
starting page: 186
ending page: 188

INCREASING WASTEWATER TREATMENT EFFICIENCY USING HYDROBIONTS
type: item
description: This article is focused on wastewater treatment using hydrobionts and was conducted in the Bukhara water supply. As a result, in order to ensure the activity of microorganisms in the treatment plant and increase the efficiency of high purification, it was achieved to ensure that the oxygen content in the aeration tank was not lower than 4.6 mg/l and the IL index was not lower than 150 mg/l. It was recommended to use the treated wastewater for irrigation of technical crops and ornamental plants
subject: Articles
  topic: section
subject: Wastewater, hydrobionts, treatment, seriobacteria, Infusoria.
  topic: keywords
creator: D. B. Bozorova
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-23
publication date: 2025-10-23
starting page: 181
ending page: 185

EVALUATING THE EFFECTIVENESS OF A NOVEL MULTIMODAL TREATMENT FOR AVASCULAR NECROSIS OF THE HEAD OF FEMUR OF POST COVID ETIOLOGY: A RETROSPECTIVE COHORT STUDY
type: item
description: Avascular necrosis (AVN) of the femoral head results from impaired blood supply, a condition increasingly observed in post-COVID-19 patients due to virus-induced microvascular damage. Conventional therapies often fail to address the vascular pathology. This retrospective cohort study, conducted from September 2020 to March 2024 in a tertiary hospital in Uzbekistan, included 350 post-COVID AVN patients divided into two groups. The case group (n=190) received standard conservative treatment plus hirudotherapy (2–3 times/week for 2 months), while the control group (n=160) received standard conservative care alone. Outcomes were evaluated through MRI staging and SF‑36 scores at baseline and every 6 months over 2 years. Results showed a significantly lower rate of femoral head collapse (10% vs. 34.4%), progression (20% vs. 51.3%), and surgery (3.2% vs. 10%) in the case group, with improved SF‑36 scores. This multimodal therapy demonstrates potential as an effective, non-surgical option for managing early-stage post-COVID AVN.
subject: Articles
  topic: section
subject: Hydrotherapy, COVID 19, Femoral head necrosis, Risedronate, total hip replacement.
  topic: keywords
creator: Sultanova Maxsuma Xudayberganovna
creator: Das Sharodiya
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-23
publication date: 2025-10-23
starting page: 176
ending page: 180

STEM GROWTH DYNAMICS IN DIFFERENT VARIETIES OF MUNG BEAN
type: item
description: In this article, the dynamics of stem growth of 15 different varieties of “AVMU” and “Zilola” and “Marjona” varieties at different vegetation periods (three-leaf stage, budding, flowering, ripening) of various mung bean varieties were studied. As a result, it was found that the most positive result was observed in variant 16 and variant 11 among 15 different varieties of “AVMU” according to the experimental system.
subject: Articles
  topic: section
subject: Mung bean varieties
  topic: keywords
creator: A. A. Komilova
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-23
publication date: 2025-10-23
starting page: 173
ending page: 175

CLINICAL AND LABORATORY PARAMETERS IN PREGNANT WOMEN WITH A HISTORY OF RECCURENT MISCARRIAGES
type: item
description: The analysis of clinical, anamnestic and laboratory examination of 80 women with hyperandrogenism syndrome in the first trimester of pregnancy was carried out in order to identify risk factors for reccurent miscarriages. Our data are consistent with the results of other studies that obesity and insulin resistance are risk factors for habitual miscarriage [6, 7]. In this case, possible pathogenetic links are insulin resistance, hyperinsulinemia, hyperandrogenism.
subject: Articles
  topic: section
subject: Reccurent miscarriages, hyperandrogenemia syndrome, pre-pregnancy preparation.
  topic: keywords
creator: Abdulazizova A. A.
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-23
publication date: 2025-10-23
starting page: 168
ending page: 172

HYGIENIC ASSESSMENT OF THE NUTRITIONAL STATUS OF POSTTERM CHILDREN
type: item
description: In this study, the nutritional characteristics and physical development indicators of 50 post-term infants were examined. According to the research results, 32% of the children were fed with artificial nutrition, while 34% had a mixed feeding pattern. Among them, 42.0% were breastfed up to one year of age, and 58.0% continued breastfeeding up to two years. Regarding the number of daily meals, 58.0% of the children ate 1–4 times per day. Additionally, 58.0% of the children received supplementary feeding up to 6 months of age. In terms of food consumption levels, 48.0% of the children consumed bread, cereals, porridge, and grain-based foods in excess of the recommended amount, while 36.0% consumed foods containing salt and sugar above the normal limit. The findings of the study revealed that most post-term infants had disrupted eating patterns. This condition may contribute to delayed physical development and an increased incidence of various diseases among these children.
subject: Articles
  topic: section
subject: Post-term newborn, nutrition, and somatic appearance of the body.
  topic: keywords
creator: Ortiqov Bobomurod Baymamatovich
creator: Hasanova Sayyora Shomurot qizi
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-21
publication date: 2025-10-21
starting page: 164
ending page: 167