FACTORS AFFECTING THE BIOAVAILABILITY OF DRUGS

Authors

  • Rakhimova Gulnora Associate Professor of the Department of Industrial Technology of Medicines, Tashkent Pharmaceutical Institute
  • Maksudova Firuza Khurshidovna Doctor of Pharmaceutical Sciences, Head of the Department of Industrial Technology of Medicines, Tashkent Pharmaceutical Institute
  • Rakhimova Oygul Associate Professor of the Department of Industrial Technology of Medicines, Tashkent Pharmaceutical Institute
  • Azimova Nargiza Abbaskhanovna Associate Professor of the Department of Industrial Technology of Medicines, Tashkent Pharmaceutical Institute
  • Lure Mark Yevgenevich 1st Year Master's Degree in Industrial Technology of Medicines

Keywords:

Pharmacokinetics, bioavalability, excipients, drug delivery systems, solid dispersion systems.

Abstract

Excipients, having certain physicochemical properties and constantly contacting with the drug, can have different effects depending on the conditions. Being inactive from a pharmacological point of view, excipients, in one way or another, affect the "drug - macroorganism " system. Approximately 40% of new chemical compounds that have shown pharmacological activity during screening have low solubility in water. Such compounds belong to classes II and IV according to the biopharmaceutical classification system. The difficulty of the transition of the drug into solution causes the lack of correlation between the dose and the pharmacological effect, low bioavailability, and, as a consequence, a decrease or distortion of the pharmacological effect.

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Published

2025-06-21

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Section

Articles

How to Cite

FACTORS AFFECTING THE BIOAVAILABILITY OF DRUGS. (2025). Web of Scientists and Scholars: Journal of Multidisciplinary Research, 3(6), 166-180. https://webofjournals.com/index.php/12/article/view/4705