ANTIMICROBIAL RESISTANCE AND OPTIMIZATION OF ANTIMICROBIAL THERAPY

Kalandarova Matlyuba Xodjiakbarovna

Authors

Kalandarova Matlyuba Xodjiakbarovna Assistant of the Department of Traditional Medicine and Pharmacology Fergana Medical Institute of Public Health

Keywords:

Resistance, betalactamase, carbapenemase, staphylococcus, pharmacokinetics, deescalation, concentration, empiricism, combination, multiresistance, transfer, antibiogram, nosocomial, susceptibility

Abstract

Antimicrobial resistance represents one of the most formidable challenges to contemporary healthcare systems worldwide. This investigation examines the molecular mechanisms underlying resistance development, identifies critical gaps in current prescribing practices, and evaluates evidence-based strategies for optimizing antimicrobial therapy. Through analysis of international surveillance data, clinical guidelines, and pharmacodynamic principles, this study demonstrates that structured antimicrobial stewardship programs combined with precision-guided therapy can substantially mitigate resistance propagation. The findings underscore the urgent need for integrated approaches encompassing diagnostic innovation, prescriber education, and policy reform to preserve antimicrobial efficacy for future generations.