ALGORITHM FOR LABORATORY EXAMINATION OF PREGNANT WOMEN WITH SUSPECTED PREECLAMPSIA

Atoyeva Shakhrizoda Ulugbekovna; Ulugbekova Shokhina Ulugbekovna; Qudratova Zebo Erkinovna

Authors

Atoyeva Shakhrizoda Ulugbekovna 1st-Year Master’s Student, Department of Clinical Laboratory Diagnostics and the Course of Clinical Laboratory Diagnostics of PGD
Ulugbekova Shokhina Ulugbekovna 3rd-Year Student Faculty of Treatment of SamSMU
Qudratova Zebo Erkinovna Scientific Superviser, PhD, Associate Professor, Department of Clinical Laboratory Diagnostics and the Course of Clinical Laboratory Diagnostics of PGD Samarkand State Medical University, Samarkand, Republic of Uzbekistan

Keywords:

Preeclampsia, diagnostic algorithm, endothelial dysfunction, angiogenic markers, NOS3, PlGF, sFlt-1, sEng, early prediction.

Abstract

Preeclampsia is a multisystem hypertensive disorder of pregnancy that remains one of the leading causes of maternal and perinatal morbidity and mortality worldwide. Early identification of women at high risk is essential for improving obstetric outcomes. Recent advances in molecular medicine have introduced novel endothelial and angiogenic biomarkers, including endothelial nitric oxide synthase (NOS3), placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and soluble endoglin (sEng). The present study proposes a diagnostic algorithm integrating clinical risk assessment, Doppler ultrasonography, and laboratory biomarkers for the early prediction and stratification of preeclampsia risk. The combined evaluation of angiogenic imbalance and endothelial dysfunction markers significantly increases diagnostic accuracy compared to traditional clinical criteria alone. Implementation of such an algorithm in routine obstetric practice may enhance early detection and allow timely preventive interventions.