ATOPIC DERMATITIS EVALUATING THE EFFICACY OF COMPLEX THERAPY AIMED AT RESTORING THE SKIN PROTECTIVE BARRIER

Authors

  • Ashurov Dilshod Davlatovich Fergana Medical Institute of Public Health Senior Teacher of the Department of Dermatovenereology and Allergology

Keywords:

atopic dermatitis, epidermal barrier, filaggrin, transepidermal water loss, ceramide, Th2 cytokines, interleukin-4, interleukin-13, dupilumab, EASI score, SCORAD, emollient, JAK inhibitor, Staphylococcus aureus colonization, epidermal differentiation complex

Abstract

Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease affecting up to 20% of children and 3% of adults globally. Epidermal barrier dysfunction - driven by filaggrin gene mutations, ceramide deficiency, and Th2-skewed immune dysregulation - constitutes the primary pathogenic event. This review evaluates the clinical efficacy of complex barrier-restorative therapies including physiological lipid emollients, dupilumab, topical JAK inhibitors, and combined protocols, using quantitative TEWL, EASI, and SCORAD metrics as outcome parameters.

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Published

2026-05-06

Issue

Vol. 4 No. 5 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

ATOPIC DERMATITIS EVALUATING THE EFFICACY OF COMPLEX THERAPY AIMED AT RESTORING THE SKIN PROTECTIVE BARRIER. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(5), 13-19. https://webofjournals.com/index.php/5/article/view/6335