EARLY RISK ASSESSMENT OF OPPORTUNISTIC INFECTIONS IN HIV-INFECTED CHILDREN USING NEUTROPHIL-TO-LYMPHOCYTE RATIO AND PLATELET-TO-LYMPHOCYTE RATIO - A PROSPECTIVE COHORT ANALYSIS

Authors

  • Gafurov Abdukayum Pattoyevich Assistant, Department of Pediatrics Fergana Medical Institute of Public Health

Keywords:

neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, opportunistic infections, pediatric HIV, immunosuppression, CD4 lymphocytes, Pneumocystis pneumonia, candidiasis, cytomegalovirus, antiretroviral therapy, systemic inflammation, lymphopenia, thrombocytopenia, hematological biomarkers, AIDS-defining conditions

Abstract

This prospective study evaluates the diagnostic utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for early opportunistic infection risk stratification in 98 HIV-infected children. Neutrophil-to-lymphocyte ratio above 3.2 demonstrated sensitivity of 88.2% and specificity of 84.6%. Combined index application increased sensitivity to 92.6%, establishing these accessible hemogram-derived biomarkers as reliable, cost-effective early warning instruments in pediatric HIV management.

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Published

2026-05-06

Issue

Vol. 4 No. 5 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

EARLY RISK ASSESSMENT OF OPPORTUNISTIC INFECTIONS IN HIV-INFECTED CHILDREN USING NEUTROPHIL-TO-LYMPHOCYTE RATIO AND PLATELET-TO-LYMPHOCYTE RATIO - A PROSPECTIVE COHORT ANALYSIS. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(5), 28-34. https://webofjournals.com/index.php/5/article/view/6337