PATHOPHYSIOLOGICAL FEATURES OF THE DEVELOPMENT OF AUTOIMMUNE REACTIONS IN VITILIGO

Authors

  • Kodirova Dilfuzakhon Abdurakhim kizi Fergana Medical Institute of Public Health Assistant of the Department of Dermatovenereology and Allergology

Keywords:

vitiligo, autoimmunity, melanocytes, cytotoxicity, autoantibodies, T-lymphocytes, HLA-A2, tyrosinase, cytokines, interferon-gamma, depigmentation, immunopathology, CD8, inflammation, pathophysiology

Abstract

Vitiligo represents a complex autoimmune dermatosis characterized by progressive melanocyte destruction mediated through cytotoxic T-lymphocyte activation, autoantibody production, and dysregulated cytokine networks. This investigation examined immunological profiles in 127 vitiligo patients, revealing significantly elevated anti-melanocyte antibodies (78.3%), altered T-cell subsets, and pro-inflammatory cytokine dominance, collectively elucidating the multifactorial autoimmune pathogenesis underlying depigmentation.

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Published

2026-05-06

Issue

Vol. 4 No. 5 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

PATHOPHYSIOLOGICAL FEATURES OF THE DEVELOPMENT OF AUTOIMMUNE REACTIONS IN VITILIGO. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(5), 55-62. https://webofjournals.com/index.php/5/article/view/6341