VITILIGO - IMMUNOPATHOGENESIS AND INVASIVE CORRECTION METHODS IN CLINICAL PRACTICE

Authors

  • Yokubov Farrukh Farhadovich Assistant of the Department of Dermatovenereology and Allergology Fergana Medical Institute of Public Health

Keywords:

Melanocyte, depigmentation, immunopathogenesis, autoreactive lymphocytes, JAK/STAT pathway, IFN-γ, CXCL10, punch grafting, melanocyte-keratinocyte transplantation, suction blister graft, repigmentation, VASI score, Koebner phenomenon, oxidative stress, segmental vitiligo.

Abstract

Vitiligo is a chronic autoimmune depigmentation disorder affecting 0.5-2% of the global population. Destruction of epidermal melanocytes is driven primarily by CD8 cytotoxic T lymphocytes through IFN-γ-CXCL9/CXCL10-CXCR3 signaling axis and JAK/STAT pathway activation. When conservative therapies fail, invasive surgical correction - including punch grafting, suction blister grafting, split-thickness skin grafting, and non-cultured melanocyte-keratinocyte transplantation - offers clinically meaningful repigmentation. This review synthesizes current immunopathogenetic data with quantitative outcomes of major invasive techniques.

Downloads

Published

2026-05-08

Issue

Vol. 4 No. 5 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

VITILIGO - IMMUNOPATHOGENESIS AND INVASIVE CORRECTION METHODS IN CLINICAL PRACTICE. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(5), 83-89. https://webofjournals.com/index.php/5/article/view/6350