CLINICAL EFFICACY OF BIOLOGICAL AND REGENERATIVE THERAPY IN CICATRICIAL ALOPECIA

Authors

  • Abduvaliyev Begali Sherali ugli Assistant of the Department of Dermatovenereology and Allergology Fergana Medical Institute of Public Health

Keywords:

Cicatricial alopecia, lichen planopilaris, frontal fibrosing alopecia, JAK inhibitor, tofacitinib, baricitinib, platelet-rich plasma, LPPAI score, follicular stem cell, pilosebaceous unit, IFN-γ, IL-17, fibrosis, TGF-β1, hair follicle regeneration.

Abstract

Cicatricial alopecia (CA) is a heterogeneous group of inflammatory disorders causing irreversible destruction of hair follicle stem cells and their replacement by fibrous tissue, affecting approximately 3-7% of patients presenting to dermatology clinics. Pathogenesis involves lymphocyte- or neutrophil-mediated attack on the pilosebaceous unit, driven by JAK/STAT signaling, Th1/Th2/Th17 cytokine imbalance, and microbial dysbiosis. This review evaluates the quantitative clinical efficacy of biological agents, JAK inhibitors, and platelet-rich plasma in stabilizing disease activity and promoting residual follicular survival.

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Published

2026-05-08

Issue

Vol. 4 No. 5 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

CLINICAL EFFICACY OF BIOLOGICAL AND REGENERATIVE THERAPY IN CICATRICIAL ALOPECIA. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(5), 98-104. https://webofjournals.com/index.php/5/article/view/6352