COMPARATIVE АNALYSIS OF LIPID METABOLISM, INFLAMMATORY MARKERS, AND ENDOTHELIAL DYSFUNCTION INDICATORS IN PATIENTS WITH ISCHEMIC HEART DISEASE AND STEATOHEPATITIS

Abstract

This study is devoted to the assessment of biochemical indicators associated with lipid metabolism, inflammatory markers, and endothelial dysfunction in patients with ischemic heart disease (IHD) combined with steatohepatitis. A total of 120 patients were included in the study: the main group consisted of 60 patients with IHD combined with steatohepatitis, while the control group included 60 patients with IHD without steatohepatitis. In all patients, total cholesterol, triglycerides, low-density and high-density lipoproteins, fibrinogen, C-reactive protein, homocysteine, and liver enzyme levels were analyzed at baseline and during follow-up at 6 and 12 months. The obtained results demonstrated that dyslipidemia, inflammatory processes, and biochemical indicators associated with endothelial dysfunction were more pronounced in the main group compared to the control group. Dynamic analysis showed that although many laboratory indicators improved after 6 months, partial increases in several markers were observed again at the 12-month stage. These findings indicate that metabolic and inflammatory processes in patients with concomitant IHD and steatohepatitis require long-term monitoring and careful management.