PROGNOSTIC SIGNIFICANCE OF CARDIOMETABOLIC AND GENETIC FACTORS AND ARTERIAL STIFFNESS INDICES IN THE DEVELOPMENT OF ISCHEMIC HEART DISEASE

Authors

  • Xursanov Alimjon Muratjonovich Cardiologist, “Vessel Clinic”

Keywords:

Ischemic heart disease, cardiometabolic factors, genetic polymorphism, APOB, PCSK9, MMP9, FADS1, SIRT1, arterial stiffness, pulse wave velocity, atherosclerosis, dyslipidemia, endothelial dysfunction, prognostic model, early diagnosis.

Abstract

This article reviews the prognostic significance of cardiometabolic and genetic factors (APOB, PCSK9, MMP9, FADS1, SIRT1) and arterial stiffness indices, assessed via pulse wave velocity, in the development of ischemic heart disease (IHD), based on an analysis of existing literature. Their molecular mechanisms, clinical correlations, and approaches to improving an integral risk model are discussed in detail.

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Published

2026-06-09

Issue

Vol. 4 No. 6 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

PROGNOSTIC SIGNIFICANCE OF CARDIOMETABOLIC AND GENETIC FACTORS AND ARTERIAL STIFFNESS INDICES IN THE DEVELOPMENT OF ISCHEMIC HEART DISEASE. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(6), 128-132. https://webofjournals.com/index.php/5/article/view/6644