EFFECTIVE MONITORING, TREATMENT AND PREVENTION OF ANEMIA CONCURRENT WITH HEART FAILURE IN THE CONDITIONS OF THE FERGANA VALLEY
Keywords:
heart failure, iron deficiency anemia, cardiorenal syndrome, hepcidin, ferric carboxymaltose, erythropoietin, transferrin saturation, ejection fraction, AFFIRM-AHF, neurohormonal activation, intravenous iron, hemoglobin, ferritin, NYHA classification, Central Asia cardiovascular burdenAbstract
This article provides a comprehensive analysis of the pathogenetic mechanisms, epidemiological burden, diagnostic approaches, and evidence-based treatment strategies for anemia coexisting with heart failure, with special emphasis on the clinical context of the Fergana Valley region. The cardiorenal anemia syndrome, hepcidin-mediated iron sequestration, erythropoietin resistance, and chronic neurohormonal activation are identified as the principal pathogenetic drivers worsening both conditions synergistically.
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