CYSTATIN C VERSUS CREATININE-BASED GLOMERULAR FILTRATION RATE ESTIMATION IN CHILDREN WITH EARLY-STAGE CHRONIC KIDNEY DISEASE - DIAGNOSTIC ACCURACY, CLINICAL UTILITY, AND PROGNOSTIC IMPLICATIONS

Authors

  • Abdullayev Sardorbek Solijon oʻgʻli Assistant, Department of Pediatrics Fergana Medical Institute of Public Health

Keywords:

Albuminuria, biomarker, chronic kidney disease, cystatin C, creatinine, glomerular filtration rate, iohexol clearance, nephroprotection, pediatric nephrology, progression, proteinuria, renal fibrosis, Schwartz equation, staging, tubular dysfunction.

Abstract

This prospective observational study compared the diagnostic accuracy of cystatin C-based and creatinine-based glomerular filtration rate equations in 112 children aged 3-15 years with stages 1-3 chronic kidney disease. Cystatin C-based estimation achieved significantly higher sensitivity for early renal decline. The combined creatinine-cystatin C equation demonstrated the best accuracy overall, supporting its routine adoption in pediatric nephrology practice.

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Published

2026-05-08

Issue

Vol. 4 No. 5 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

CYSTATIN C VERSUS CREATININE-BASED GLOMERULAR FILTRATION RATE ESTIMATION IN CHILDREN WITH EARLY-STAGE CHRONIC KIDNEY DISEASE - DIAGNOSTIC ACCURACY, CLINICAL UTILITY, AND PROGNOSTIC IMPLICATIONS. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(5), 90-97. https://webofjournals.com/index.php/5/article/view/6351