THE ROLE OF HYPOXIA-INDUCIBLE FACTOR HIF-1α IN THE PATHOGENESIS OF INTRAPARTUM FETAL DEATH IN PREECLAMPSIA

Authors

  • Jabborova Munisxon Abdubanon qizi Assistant of Fergana Public Health Medical Institute

Keywords:

HIF-1α, placental dysfunction, preeclampsia, hypoxia-inducible factor, fetoplacental insufficiency, intrapartum fetal death, genetic polymorphism, endothelial dysfunction.

Abstract

The purpose of this study was to investigate the role of hypoxia-inducible factor HIF-1α in the formation of fetoplacental insufficiency and the development of intrapartum fetal death in preeclampsia. The study included analysis of molecular genetic data in conjunction with Doppler measurements of fetoplacental blood flow. The findings established that HIF-1α hyperexpression is associated with endothelial cell apoptosis, reduced angiogenesis, and critical abnormalities in Doppler indices that precede acute intrapartum fetal hypoxia in preeclampsia.

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Published

2026-01-12

Issue

Vol. 4 No. 1 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

THE ROLE OF HYPOXIA-INDUCIBLE FACTOR HIF-1α IN THE PATHOGENESIS OF INTRAPARTUM FETAL DEATH IN PREECLAMPSIA. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(1), 73-78. https://webofjournals.com/index.php/5/article/view/5818