MOLECULAR-PATHOGENETIC ASPECTS OF HIF-1α PARTICIPATION IN THE DEVELOPMENT OF INTRANATAL FETAL DEATH IN PREECLAMPSIA

Authors

  • Jabborova Munisxon Abdubanon qizi Assistant, Department of Obstetrics and Gynecology Fergana Public Health Medical Institute

Keywords:

HIF-1α, preeclampsia, intranatal fetal death, hypoxia-inducible factor, placental hypoxia, sFlt-1, PlGF, trophoblast dysfunction, immunohistochemistry, Western blot, angiogenic imbalance, molecular pathogenesis, oxidative stress, fetoplacental insufficiency, perinatology.

Abstract

This study investigates the role of hypoxia-inducible factor 1-alpha (HIF-1α) in the molecular pathogenesis of intranatal fetal death complicating preeclampsia. Using immunohistochemistry, Western blotting, and ELISA analysis of placental tissue and serum samples from 65 women, we demonstrate significantly elevated HIF-1α expression in preeclamptic placentas, correlating with sFlt-1 upregulation, PlGF suppression, and fatal perinatal outcomes.

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Published

2026-05-20

Issue

Vol. 4 No. 5 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

MOLECULAR-PATHOGENETIC ASPECTS OF HIF-1α PARTICIPATION IN THE DEVELOPMENT OF INTRANATAL FETAL DEATH IN PREECLAMPSIA. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(5), 190-194. https://webofjournals.com/index.php/5/article/view/6425